Homoarginin-hydrochlorid | 62414-64-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Homoarginin-hydrochlorid
• 英文别名: N⁶-carbamimidoyl-DL-lysine ; hydrochloride；N⁶-Carbamimidoyl-DL-lysin; Hydrochlorid；2-Amino-6-(diaminomethylideneamino)hexanoic acid;hydron;chloride；2-amino-6-(diaminomethylideneamino)hexanoic acid;hydron;chloride
• CAS: 62414-64-6
• 化学式: C₇H₁₆N₄O₂*ClH
• 分子量: 224.691
• InChiKey: YMKBVNVCKUYUDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.53
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  128
• 氢给体数：
  5
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Homoarginin-hydrochlorid 在 氢溴酸 、 三氟乙酸酐 作用下， 生成 2,3,6,7-Tetrahydro-3-iminoimidazol<1,5-a>pyridin-1(5H)-on
  参考文献：
  名称：

  Klein, Christian; Schulz, Guenter; Steglich, Wolfgang, Liebigs Annalen der Chemie, 1983, # 9, p. 1623 - 1637

  摘要：

  DOI：

文献信息

• Structure-Activity Relationships of Alpha-Human Atrial Natriuretic Peptide (.ALPHA.-hANP) Analogs: Role of Charged Groups in .ALPHA.-hANP.
  作者：Yoshiharu MINAMITAKE、Yasuo KITAJIMA、Mayumi FURUYA、Maki YOSHIDA、Shoji TANAKA

  DOI：10.1248/cpb.39.2005

  日期：——

  To determine whether the addition of a methylene unit in the side chain of the Asp or Arg residue in α-human atrial natriuretic peptide (α-hANP) influences its biological activity, analogs of α-hANP, [Glu13]-α-hANP (7-28) (1), [Aad13]-α-hANP (7-28) (2), and [Harn]-α-hANP(7-28) (where n is any possible combination of 11, 14 and 27) (3-9), where the original Asp or Arg residue was replaced by a homo-amino acid, were synthesized by the solid-phase synthesis method. All the analogs were evaluated for their receptor binding, cyclic guanosine monophosphate (cGMP) accumulation activity in rat vascular smooth muscle cells (VSMC), and for vasorelaxant activity employing rat aorta. 1 and 2 were 0.9 and 0.03 times as potent as α-hANP (7-28), respectively, in binding. Har-containing analogs (3-9) were as potent as α-hANP (7-28) in binding. Among the Har-containing analogs, [Har11, 14]-α-hANP (7-28) (6) and [Har11, 27]-α-hANP (7-28) (7) were remarkably vasorelaxant active, being 4.2 and 5.3 times potent than α-hANP (7-28), respectively, in spite of relatively lower cGMP accumulation activity in the case of 7. The roles of the chargeable amino acid residues in biological activity are discussed.

  为了确定在 α-人心房利钠肽（α-hANP）的 Asp 或 Arg 残基侧链中添加亚甲基单元是否会影响其生物活性，α-hANP 的类似物 [Glu13]-α-hANP (7-28) (1)、固相合成法合成了[Aad13]-α-hANP（7-28）（2）和[Harn]-α-hANP（7-28）（其中 n 是 11、14 和 27 的任意组合）（3-9）的类似物。对所有类似物进行了受体结合、大鼠血管平滑肌细胞（VSMC）中环磷酸鸟苷（cGMP）积累活性以及大鼠主动脉血管舒张活性的评估。1 和 2 的结合力分别是 α-hANP （7-28）的 0.9 倍和 0.03 倍。含 Har 的类似物（3-9）与 α-hANP (7-28) 的结合力相同。在含 Har 的类似物中，[Har11, 14]-α-hANP (7-28) (6)和[Har11, 27]-α-hANP (7-28) (7)具有显著的血管舒张活性，分别是 α-hANP (7-28) 的 4.2 倍和 5.3 倍，尽管 7 的 cGMP 积聚活性相对较低。
• Recording sheets containing amino acids, hydroxy acids, and polycarboxyl compounds
  申请人：XEROX CORPORATION

  公开号：EP0667246A1

  公开（公告）日：1995-08-16

  A recording sheet which comprises a paper substrate and a material selected from the group consisting of monomeric amino acids, monomeric hydroxy acids, monomeric polycarboxyl compounds, and mixtures thereof. Another embodiment of the present invention is directed to a recording sheet which comprises a substrate and a material selected from the group consisting of monomeric amino acids, monomeric hydroxy acids, and mixtures thereof.

  一种记录纸，它包括纸基材和选自单体氨基酸、单体羟基酸、单体聚羧基化合物及其混合物组成的组的材料。本发明的另一个实施方案涉及一种记录纸，它包括基材和选自单体氨基酸、单体羟基酸及其混合物组成的组的材料。
• KLEIN, C.;SCHULZ, G.;STEGLICH, W., LIEBIGS ANN. CHEM., 1983, N 9, 1623-1637
  作者：KLEIN, C.、SCHULZ, G.、STEGLICH, W.

  DOI：——

  日期：——
• COMPOSITIONS FOR NASAL ADMINISTRATION CONTAINING POLAR METABOLITES OF OPIOID ANALGESICS
  申请人：DANBIOSYST UK LIMITED

  公开号：EP0625044A1

  公开（公告）日：1994-11-23
• METHOD AND COMPOSITION FOR TREATING ARGINASE 1 DEFICIENCY
  申请人：AERase, Inc.

  公开号：EP3720476A1

  公开（公告）日：2020-10-14

表征谱图