[4-benzenesulfonyl-2-(2-chlorophenyl)oxazol-5-yl]-dimethylamine | 301158-50-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [4-benzenesulfonyl-2-(2-chlorophenyl)oxazol-5-yl]-dimethylamine
• 英文别名: 4-(benzenesulfonyl)-2-(2-chlorophenyl)-N,N-dimethyl-1,3-oxazol-5-amine
• CAS: 301158-50-9
• 化学式: C₁₇H₁₅ClN₂O₃S
• 分子量: 362.837
• InChiKey: ZGOUDMAXJJTRQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  71.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• SULFONYLOXAZOLAMINE ALS THERAPEUTISCHE WIRKSTOFFE
  申请人：MERCK PATENT GmbH

  公开号：EP1140875A1

  公开（公告）日：2001-10-10
• METHODS FOR IDENTIFYING INHIBITORS OF SOLUTE TRANSPORTERS
  申请人：Verkman Alan S.

  公开号：US20100190796A1

  公开（公告）日：2010-07-29

  Provided herein are methods for identifying and characterizing agents that alter the volume of a cell. Methods are provided for rapid screening and identification of an agent that alters the capability of a small, neutrally charged solute transporter to transport the solute across a cell membrane. The methods described herein may be used to identify and characterize inhibitors of urea transporters, to identify and characterize inhibitors of aquaporins, and to identify and characterize inhibitors of other small, neutrally charged solutes such as glucose.
• PHENYLSULFOXYOXAZOLE COMPOUND INHIBITORS OF UREA TRANSPORTERS
  申请人：Verkman Alan S.

  公开号：US20100305105A1

  公开（公告）日：2010-12-02

  Provided herein are small molecule compounds that alter the transport activity of solute transporters, particularly urea transporters. The compounds described herein belong to the phenylsulfoxyoxazole, phenylsulfoxyimidazole, phenylsulfoxythiazole class of compounds. The compounds described herein are useful for increasing solute clearance in states of fluid overload and for treating cardiovascular, renal, and metabolic diseases, disorders, and conditions. Methods for identifying and using these agents that inhibit urea transporters are described herein.
• US6441013B1
  申请人：——

  公开号：US6441013B1

  公开（公告）日：2002-08-27
• US8394788B2
  申请人：——

  公开号：US8394788B2

  公开（公告）日：2013-03-12