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(6Z,15Z)-11-((Z)-dec-4-enyl)henicosa-6,15-dien-10-yl 4-(dimethylamino)butanoate | 1450888-87-5

中文名称
——
中文别名
——
英文名称
(6Z,15Z)-11-((Z)-dec-4-enyl)henicosa-6,15-dien-10-yl 4-(dimethylamino)butanoate
英文别名
[(6Z,15Z)-11-[(Z)-dec-4-enyl]henicosa-6,15-dien-10-yl] 4-(dimethylamino)butanoate
(6Z,15Z)-11-((Z)-dec-4-enyl)henicosa-6,15-dien-10-yl 4-(dimethylamino)butanoate化学式
CAS
1450888-87-5
化学式
C37H69NO2
mdl
——
分子量
559.96
InChiKey
VJKJNDSNJIDCOU-PUXVMRFKSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    13.1
  • 重原子数:
    40
  • 可旋转键数:
    30
  • 环数:
    0.0
  • sp3杂化的碳原子比例:
    0.81
  • 拓扑面积:
    29.5
  • 氢给体数:
    0
  • 氢受体数:
    3

反应信息

点击查看最新优质反应信息

文献信息

  • COMPOSITIONS AND METHODS FOR DELIVERING MESSENGER RNA
    申请人:PROTIVA BIOTHERAPEUTICS, INC.
    公开号:US20160151284A1
    公开(公告)日:2016-06-02
    The present invention provides compositions comprising mRNA molecules encapsulated within lipid particles. The lipid particles comprise a cationic lipid, a non-cationic lipid, and an mRNA molecule that is encapsulated within the lipid particle. The compositions are useful, for example, to introduce the mRNA molecules into a human subject where they are translated to produce a polypeptide that functions to ameliorate one or more symptoms of a disease. The invention also provides cationic lipids that are useful for preparing the compositions of the invention.
    本发明提供了包含mRNA分子封装在脂质颗粒内的组合物。脂质颗粒包括一个阳离子脂质、一个非阳离子脂质和一个被封装在脂质颗粒内的mRNA分子。这些组合物可用于将mRNA分子引入人体受试者,从而产生一个多肽,其功能是改善一种或多种疾病症状。本发明还提供了用于制备上述组合物的阳离子脂质。
  • TRIALKYL CATIONIC LIPIDS AND METHODS OF USE THEREOF
    申请人:PROTIVA BIOTHERAPEUTICS, INC.
    公开号:US20150064242A1
    公开(公告)日:2015-03-05
    The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel, trialkyl, cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses.
    本发明提供了用于向细胞传递治疗剂的组合物和方法。特别地,这些包括新型的三烷基阳离子脂质和核酸-脂质颗粒,这些颗粒提供了核酸的高效封装和在体内有效地传递该封装的核酸到细胞的方法。本发明的组合物非常有效,因此在相对较低的剂量下允许有效地抑制特定靶蛋白。
  • Trialkyl cationic lipids and methods of use thereof
    申请人:PROTIVA BIOTHERAPEUTICS, INC.
    公开号:US09352042B2
    公开(公告)日:2016-05-31
    The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel, trialkyl, cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses.
    本发明提供了用于向细胞传递治疗剂的组合物和方法。特别地,这些组合物包括新型的三烷基阳离子脂质和核酸-脂质颗粒,它们提供了对核酸的高效封装和对封装的核酸在体内的高效递送。本发明的组合物具有高度的效力,因此可以在相对较低的剂量下有效地降低特定靶蛋白的表达。
  • Compositions and methods for delivering messenger RNA
    申请人:ARBUTUS BIOPHARMA CORPORATION
    公开号:US11191849B2
    公开(公告)日:2021-12-07
    The present invention provides compositions comprising nucleic acid molecules, such as mRNA molecules, encapsulated within lipid particles. The compositions are useful, for example, to introduce the mRNA molecules into a human subject where they are translated to produce a polypeptide that functions to ameliorate one or more symptoms of a disease.
    本发明提供的组合物包含封装在脂质颗粒中的核酸分子,如 mRNA 分子。例如,这些组合物可用于将 mRNA 分子导入人体,在人体中翻译产生多肽,从而改善疾病的一种或多种症状。
  • NUCLEIC-ACID CONTAINING LIPID NANO-PARTICLE AND USE THEREOF
    申请人:Takeda Pharmaceutical Company Limited
    公开号:US20210052646A1
    公开(公告)日:2021-02-25
    The present invention provides a lipid nanoparticle containing the following (a) to (c): (a) a nucleic acid encoding a chimeric antigen receptor (CAR) or an exogenous T cell receptor (TCR); (b) a cationic lipid; and (c) a non-cationic lipid. The present invention also provides a CAR- or exogenous TCR-zo expressing immunocyte obtained by introducing the lipid nanoparticle into in vivo or ex vivo T cells, and an in vivo or ex vivo therapeutic approach using the immunocytes for disease such as cancer and the like.
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