N-[2-hydroxy(phenyl)methyl-4,5-dimethoxyphenyl]acetamide | 375833-72-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[2-hydroxy(phenyl)methyl-4,5-dimethoxyphenyl]acetamide
• 英文别名: N-{2-[hydroxy(phenyl)methyl]-4,5-dimethoxyphenyl}acetamide；N-[2-[hydroxy(phenyl)methyl]-4,5-dimethoxyphenyl]acetamide
• CAS: 375833-72-0
• 化学式: C₁₇H₁₉NO₄
• 分子量: 301.342
• InChiKey: YQHJCSXALXAEHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  67.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-[2-hydroxy(phenyl)methyl-4,5-dimethoxyphenyl]acetamide 在 盐酸 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 24.0h， 生成 1-(5,6-dimethoxy-3-phenyl-1H-2-indolyl)-4,4-dimethyl-3-pentanone
  参考文献：
  名称：

  Simple route to 3-(2-indolyl)-1-propanones via a furan recyclization reaction

  摘要：

  A simple route to 1-R-3-(2-indolyl)-1-propanones has been elaborated based on recyclization of 2-(2-aminobenzyl)furan derivatives. Being a modification of the Reissert indole synthesis, our approach employs the furan ring as a source of carbonyl function. This approach is general and allows varying of substituents in aromatic ring as well as in 3-position of indole nucleus. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.10.056
• 作为产物：
  描述：

  3,4-二甲氧基二苯甲酮 在 sodium tetrahydroborate 、 硝酸 、 铁粉 、 溶剂黄146 作用下， 以 乙醇 、 水 、 乙酸乙酯 为溶剂， 反应 6.75h， 生成 N-[2-hydroxy(phenyl)methyl-4,5-dimethoxyphenyl]acetamide
  参考文献：
  名称：

  Simple route to 3-(2-indolyl)-1-propanones via a furan recyclization reaction

  摘要：

  A simple route to 1-R-3-(2-indolyl)-1-propanones has been elaborated based on recyclization of 2-(2-aminobenzyl)furan derivatives. Being a modification of the Reissert indole synthesis, our approach employs the furan ring as a source of carbonyl function. This approach is general and allows varying of substituents in aromatic ring as well as in 3-position of indole nucleus. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.10.056

文献信息

• Simple route to 3-(2-indolyl)-1-propanones via a furan recyclization reaction
  作者：Alexander V. Butin、Sergey K. Smirnov、Tatyana A. Stroganova、Wolfgang Bender、Gennady D. Krapivin

  DOI：10.1016/j.tet.2006.10.056

  日期：2007.1

  A simple route to 1-R-3-(2-indolyl)-1-propanones has been elaborated based on recyclization of 2-(2-aminobenzyl)furan derivatives. Being a modification of the Reissert indole synthesis, our approach employs the furan ring as a source of carbonyl function. This approach is general and allows varying of substituents in aromatic ring as well as in 3-position of indole nucleus. (c) 2006 Elsevier Ltd. All rights reserved.