N2-(4-fluorophenyl)-4-methoxybenzene-1,2-diamine | 582310-30-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N2-(4-fluorophenyl)-4-methoxybenzene-1,2-diamine
• 英文别名: 2-N-(4-fluorophenyl)-4-methoxybenzene-1,2-diamine
• CAS: 582310-30-3
• 化学式: C₁₃H₁₃FN₂O
• mdl: MFCD24977688
• 分子量: 232.257
• InChiKey: KTLYPJGQIALFRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.076
• 拓扑面积：
  47.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-噻吩甲醛 、 N2-(4-fluorophenyl)-4-methoxybenzene-1,2-diamine 在 sodium hydrogen sulfite 作用下， 以 NaHSO₃ 、 乙醇 为溶剂， 生成 6-Methoxy-1-(4-fluorophenyl)-2-(3-thienyl)-1H-benzimidazole
  参考文献：
  名称：

  1-Phenyl-2-heteroaryl-substituted benzimdazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives

  摘要：

  本文介绍了新的苯并咪唑衍生物，它们的制备方法以及它们用于生产用于治疗和预防与微神经胶质细胞活化和T细胞介导的免疫性疾病相关的药物，以及含有新的苯并咪唑衍生物的制药制剂。

  公开号：

  US20030229085A1
• 作为产物：
  描述：

  (4-fluorophenyl)-(4-methoxyphenyl)diazene 在 盐酸 、 水 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.5h， 以70.56%的产率得到N2-(4-fluorophenyl)-4-methoxybenzene-1,2-diamine
  参考文献：
  名称：

  在不同溶剂中辐照 4-甲氧基-4'-取代偶氮苯选择性合成 N-芳基苯-1,2-二胺或 1-芳基苯并咪唑。

  摘要：

  研究了 4-甲氧基偶氮苯的溶剂可控光反应得到 1-芳基-1H-苯并咪唑或 N-芳基苯-1,2-二胺。4-甲氧基偶氮苯在含有 0.5 M 盐酸的 DMF 中辐照产生 N 2-aryl-4-methoxybenzo-1,2-diamines 作为主要产物，而在含有 0.16 M 盐酸的乙缩醛中辐照产生 1-aryl-6-主要产品为甲氧基-2-甲基-1H-苯并咪唑。还讨论了解释选择性的可能反应机制。

  DOI：

  10.1039/d0ra10068d

文献信息

• 1-Phenyl-2-heteroaryl-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
  申请人：Blume Thorsten

  公开号：US20050267160A1

  公开（公告）日：2005-12-01

  New benzimidazole derivatives are described, their production and their use for the production of pharmaceutical agents for treatment and prevention of diseases that are associated with a microglia activation and T-cell-mediated immunological diseases, as well as pharmaceutical preparations that contain the new benzimidazole derivatives.

  本文描述了新的苯并咪唑衍生物，它们的生产以及它们用于制备与微胶质细胞激活和T细胞介导的免疫性疾病有关的药物治疗和预防疾病的用途，以及包含新的苯并咪唑衍生物的制药制剂。
• 1-phenyl-2-heteroaryl-substituted benzimdazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
  申请人：Blume Thorsten

  公开号：US06962932B2

  公开（公告）日：2005-11-08

  New benzimidazole derivatives are described, their production and their use for the production of pharmaceutical agents for treatment and prevention of diseases that are associated with a microglia activation and T-cell-mediated immunological diseases, as well as pharmaceutical preparations that contain the new benzimidazole derivatives.

  本文描述了新的苯并咪唑衍生物，它们的生产以及它们用于生产用于治疗和预防与小胶质细胞激活和T细胞介导的免疫性疾病相关的药物制剂，以及含有新苯并咪唑衍生物的药物制剂。
• 1-phenyl-2-heteroaryl-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
  申请人：Bayer Schering Pharma Aktiengesellschaft

  公开号：US07683081B2

  公开（公告）日：2010-03-23

  New benzimidazole derivatives are described, their production and their use for the production of pharmaceutical agents for treatment and prevention of diseases that are associated with a microglia activation and T-cell-mediated immunological diseases, as well as pharmaceutical preparations that contain the new benzimidazole derivatives.

  本文描述了新的苯并咪唑衍生物，它们的生产以及它们用于生产治疗与微胶质细胞活化和T细胞介导的免疫性疾病相关的药物制剂，以及包含新苯并咪唑衍生物的药物制剂。
• The selective synthesis of <i>N</i>-arylbenzene-1,2-diamines or 1-arylbenzimidazoles by irradiating 4-methoxy-4′-substituted-azobenzenes in different solvents
  作者：Po-Yi Chen、Chi-Wei Hsu、Tong-Ing Ho、Jinn-Hsuan Ho

  DOI：10.1039/d0ra10068d

  日期：——

  The solvent-controllable photoreaction of 4-methoxyazobenzenes to afford 1-aryl-1H-benzimidazoles or N-arylbenzene-1,2-diamines has been studied. The irradiation of 4-methoxyazobenzenes in DMF containing 0.5 M hydrochloric acid provided N 2-aryl-4-methoxybenzene-1,2-diamines as the major product, while irradiation in acetal containing 0.16 M hydrochloric acid led to 1-aryl-6-methoxy-2-methyl-1H-benzimidazoles

  研究了 4-甲氧基偶氮苯的溶剂可控光反应得到 1-芳基-1H-苯并咪唑或 N-芳基苯-1,2-二胺。4-甲氧基偶氮苯在含有 0.5 M 盐酸的 DMF 中辐照产生 N 2-aryl-4-methoxybenzo-1,2-diamines 作为主要产物，而在含有 0.16 M 盐酸的乙缩醛中辐照产生 1-aryl-6-主要产品为甲氧基-2-甲基-1H-苯并咪唑。还讨论了解释选择性的可能反应机制。
• 1-Phenyl-2-heteroaryl-substituted benzimdazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
  申请人：Schering Aktiengesellschaft

  公开号：US20030229085A1

  公开（公告）日：2003-12-11

  New benzimidazole derivatives are described, their production and their use for the production of pharmaceutical agents for treatment and prevention of diseases that are associated with a microglia activation and T-cell-mediated immunological diseases, as well as pharmaceutical preparations that contain the new benzimidazole derivatives.

  本文介绍了新的苯并咪唑衍生物，它们的制备方法以及它们用于生产用于治疗和预防与微神经胶质细胞活化和T细胞介导的免疫性疾病相关的药物，以及含有新的苯并咪唑衍生物的制药制剂。