1-[(2-Chloro-1,3-thiazol-5-yl)methyl]piperidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-[(2-Chloro-1,3-thiazol-5-yl)methyl]piperidine
• 英文别名: 2-chloro-5-(piperidin-1-ylmethyl)-1,3-thiazole
• 化学式: C₉H₁₃ClN₂S
• 分子量: 216.73
• InChiKey: QDFNRYQWJPYGOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  44.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(2-(tert-butoxycarbonylamino)phenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide 、 1-[(2-Chloro-1,3-thiazol-5-yl)methyl]piperidine 以to give the title compound (271 mg, >100%) which的产率得到N-(2-t-butoxycarbonylaminophenyl)-4-[5-(piperidin-1-ylmethyl)-1,3-thiazol-2-yl]benzamide
  参考文献：
  名称：

  BENZAMIDE DERIVATIVES USEFUL AS HISTONE DEACETYLASE INHIBITORS

  摘要：

  本发明涉及一种化合物的公式（I），其中环A是杂环基；m为0-4，每个R1是羟基、卤素、三氟甲基和氰基等基团；R2为卤素，n为0-2；每个R4是羟基、卤素、三氟甲基和氰基等基团；p为0-4；R3为氨基或羟基；或其药学上可接受的盐或体内水解酯或酰胺；制备它们的过程，含有它们的制药组合物以及它们在治疗组织脱乙酰化酶介导的疾病或医学状况中的使用。

  公开号：

  US20100331329A1

文献信息

• Benzamide derivatives useful as histone deacetylase inhibitors
  申请人：Stokes Sophie Elizabeth Elaine

  公开号：US20050171103A1

  公开（公告）日：2005-08-04

  The invention concerns a compound of the formula (I) wherein Ring A is heterocyclyl; m is 0-4 and each R 1 is a group such as hydroxy, halo, trifluoromethyl and cyano; R 2 is, halo and n is 0-2; and each R 4 is a group such as hydroxy, halo, trifluoromethyl and cyano; p is 0-4; and R 3 is amino or hydroxy; or pharmaceutically-acceptable salts or in-vivo-hydrolysable ester or amide thereof processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical condions mediated by histone deacetylase.

  本发明涉及一种化合物，其化学式为（I），其中环A为杂环基；m为0-4，每个R1是羟基、卤素、三氟甲基和氰基等基团；R2为卤素，n为0-2；每个R4是羟基、卤素、三氟甲基和氰基等基团；p为0-4；R3为氨基或羟基；或其药学可接受的盐或体内可水解的酯或酰胺，以及制备它们的过程，含有它们的制药组合物以及它们在治疗组织脱乙酰化酶介导的疾病或医学状况中的用途。
• SUBSTITUTED 1, 4-DIOXA-8-AZASPIRO Ý4,5¨DECANES USEFUL AS FUNGICIDES AND A PROCESS FOR THE PREPARATION THEREOF
  申请人：Council of Scientific & Industrial Research

  公开号：EP2410854A2

  公开（公告）日：2012-02-01
• US8247562B2
  申请人：——

  公开号：US8247562B2

  公开（公告）日：2012-08-21
• [EN] SUBSTITUTED 1, 4-DIOXA-8-AZASPIRO [4,5] DECANES USEFUL AS FUNGICIDES AND A PROCESS FOR THE PREPARATION THEREOF<br/>[FR] 1,4-DIOXA-8-AZASPIRO[4,5]DÉCANES SUBSTITUÉS UTILISÉS COMME FONGICIDES ET LEUR PROCÉDÉ DE PRÉPARATION
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2010109299A2

  公开（公告）日：2010-09-30

  This invention relates provides novel substituted 1, 4-dioxa-8-azaspiro[4,5 ]decanc of general formula (1), wherein R1 is selected from phenethyl, 4, 6-dimethoxypyrimidin- 2-yl and (2-chloro-5-thiazolyl) methyl and R2 is selected from the group consisting of hydroxy, 4-bromo-2-chlorophenoxy, morpholin-4-yl, (2-chloro-5-thiazolyl) methyloxy, benzyloxy, phenylsulfanyl, benzotriazol- 1 -yl and 5-chloro-2-fluoroanilino. The present invention also relates to a process for the preparation of novel substituted l,4-dioxa-8- azaspiro[4,5]decanes of general formula (1). The novel substituted l,4-dioxa-8- azaspiro[4,5]decane of general formula ( 1) has fungicidal activity.
• BENZAMIDE DERIVATIVES USEFUL AS HISTONE DEACETYLASE INHIBITORS
  申请人：Stokes Elaine Sophie Elizabeth

  公开号：US20090029991A1

  公开（公告）日：2009-01-29

  The invention concerns a compound of the formula (I) wherein Ring A is heterocyclyl; m is 0-4 and each R 1 is a group such as hydroxy, halo, trifluoromethyl and cyano; R 2 is halo and n is 0-2; and each R 4 is a group such as hydroxy, halo, trifluoromethyl and cyano; p is 0-4; and R 3 is amino or hydroxy; or pharmaceutically-acceptable salts or in-vivo-hydrolysable ester or amide thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by histone deacetylase.

  本发明涉及式（I）的化合物，其中环A是杂环基；m为0-4，每个R1是羟基、卤素、三氟甲基和氰基等基团；R2是卤素，n为0-2；每个R4是羟基、卤素、三氟甲基和氰基等基团；p为0-4；R3是氨基或羟基；或其药学上可接受的盐或体内可水解的酯或酰胺，其制备方法，含有它们的制药组合物以及它们在通过组蛋白去乙酰化酶介导的疾病或医学情况的治疗中的应用。