1,2,2-trimethyl-1-propyl diphenylphosphinite | 1202278-82-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,2,2-trimethyl-1-propyl diphenylphosphinite
• CAS: 1202278-82-7
• 化学式: C₁₈H₂₃OP
• 分子量: 286.354
• InChiKey: PLIGBRGPESXKEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.49
• 重原子数：
  20.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  1,2,2-trimethyl-1-propyl diphenylphosphinite 在 双氧水 作用下， 以 水 、 苯 为溶剂， 反应 1.0h， 以68%的产率得到1,2,2-trimethyl-1-propyl diphenylphosphinate
  参考文献：
  名称：

  Synthesis and characterisation of severely hindered P-OR compounds

  摘要：

  P-Cl substrates were converted into their P-OR analogues from hindered alcohols using an amine base. Where the system was severely hindered, more forcing conditions were required that necessitated the presence of a metal alkoxide nucleophile before successful reactions were observed. In some instances, the products were thermally unstable and reverted to alkenes by elimination reactions, while others were sensitive to moisture. Here, hydrolysis products prevailed if moisture was not rigorously excluded. Details are presented to obtain the P(III) and P(V) esters, diesters and half esters. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.10.008
• 作为产物：
  描述：

  3,3-二甲基-2-丁醇 、 二苯基氯化膦 在 三乙胺 作用下， 以 苯 为溶剂， 以38%的产率得到1,2,2-trimethyl-1-propyl diphenylphosphinite
  参考文献：
  名称：

  Synthesis and characterisation of severely hindered P-OR compounds

  摘要：

  P-Cl substrates were converted into their P-OR analogues from hindered alcohols using an amine base. Where the system was severely hindered, more forcing conditions were required that necessitated the presence of a metal alkoxide nucleophile before successful reactions were observed. In some instances, the products were thermally unstable and reverted to alkenes by elimination reactions, while others were sensitive to moisture. Here, hydrolysis products prevailed if moisture was not rigorously excluded. Details are presented to obtain the P(III) and P(V) esters, diesters and half esters. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.10.008

文献信息

• Synthesis and characterisation of severely hindered P-OR compounds
  作者：D. Bradley G. Williams、Takelani E. Netshiozwi

  DOI：10.1016/j.tet.2009.10.008

  日期：2009.11

  P-Cl substrates were converted into their P-OR analogues from hindered alcohols using an amine base. Where the system was severely hindered, more forcing conditions were required that necessitated the presence of a metal alkoxide nucleophile before successful reactions were observed. In some instances, the products were thermally unstable and reverted to alkenes by elimination reactions, while others were sensitive to moisture. Here, hydrolysis products prevailed if moisture was not rigorously excluded. Details are presented to obtain the P(III) and P(V) esters, diesters and half esters. (C) 2009 Elsevier Ltd. All rights reserved.