N-butyl-2,4-dihydroxy-3,3-dimethylbutyramide | 43180-76-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-butyl-2,4-dihydroxy-3,3-dimethylbutyramide
• 英文别名: N-butyl-pantamide；(+/-)-2.4-Dihydroxy-3.3-dimethyl-buttersaeure-butylamid；N-Butyl-pantamid；(+/-)-N-Pantoyl-butylamin；N-butyl-2,4-dihydroxy-3,3-dimethylbutanamide
• CAS: 43180-76-3
• 化学式: C₁₀H₂₁NO₃
• 分子量: 203.282
• InChiKey: JJERDAACTRCHOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-butyl-2,4-dihydroxy-3,3-dimethylbutyramide 在 重铬酸吡啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以80%的产率得到1-butyl-4,4-dimethylpyrrolidine-2,3,5-trione
  参考文献：
  名称：

  Enantioselective hydrogenation of pyrrolidine-2,3,5-triones over the Pt–cinchonidine system

  摘要：

  1- and I-Substituted pyrrolidine-2,3,5-triones 5, 6 and 9 have been synthesized and hydrogenated to 3-hydroxy derivatives 10-12 with 17-91% ee using a 5 wt% Pt/Al2O3 catalyst in the presence of small amounts of cinchonidine. The influence of substituents on the enantioselectivity is discussed. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(98)00499-6
• 作为产物：
  描述：

  正丁胺 、 DL-泛酰内酯 以 甲醇 为溶剂， 反应 3.0h， 以89%的产率得到N-butyl-2,4-dihydroxy-3,3-dimethylbutyramide
  参考文献：
  名称：

  Enantioselective hydrogenation of pyrrolidine-2,3,5-triones over the Pt–cinchonidine system

  摘要：

  1- and I-Substituted pyrrolidine-2,3,5-triones 5, 6 and 9 have been synthesized and hydrogenated to 3-hydroxy derivatives 10-12 with 17-91% ee using a 5 wt% Pt/Al2O3 catalyst in the presence of small amounts of cinchonidine. The influence of substituents on the enantioselectivity is discussed. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(98)00499-6

文献信息

• ENDOPROSTHESIS HAVING AND ACTIVE SUSBTANCE COATING
  申请人：Hemoteq AG

  公开号：US20170014364A1

  公开（公告）日：2017-01-19

  The present invention relates to an endoprosthesis with a drug coating comprising or consisting of at least one antibiotic agent and at least one further substance having the following general

  本发明涉及一种具有药物涂层的内植入物，该药物涂层包括或由至少一种抗生素和至少一种具有以下一般性质的进一步物质组成。
• PHOTOSENSITIVE COMPOSITION, PLANOGRAPHIC PRINTING PLATE PRECURSOR, POLYURETHANE, AND METHOD FOR PRODUCING POLYURETHANE
  申请人：FUJIFILM CORPORATION

  公开号：US20140134540A1

  公开（公告）日：2014-05-15

  A photosensitive composition includes (A) a polyurethane obtained by reacting a diol component including a compound represented by the following Formula (I) with a polyisocyanate component; and (B) a photosensitive component. In Formula (I), A represents a single bond, or a divalent linking group including an atom selected from the group consisting of a carbon atom, a hydrogen atom, and an oxygen atoms; B represents a monovalent organic group; each of R 1 to R 5 independently represents a hydrogen atom or an alkyl group; m represents an integer from 0 to 3; n represents an integer from 0 to 3; and m+n is not zero.

  一种光敏组合物，包括(A)聚氨酯和(B)光敏组分。聚氨酯是通过将包括以下式(I)的化合物的二元醇组分与多异氰酸酯组分反应而获得的。在式(I)中，A表示单键，或者包括从群组中选择的原子的双价连接基团，该群组包括碳原子，氢原子和氧原子；B表示单价有机基团；R1到R5中的每一个独立地表示氢原子或烷基；m表示从0到3的整数；n表示从0到3的整数；且m+n不为零。
• Shive; Snell, Journal of Biological Chemistry, 1945, vol. 160, p. 287
  作者：Shive、Snell

  DOI：——

  日期：——
• Substituted 4(5H)-oxazolones and their salts. 3. Synthesis of 4(5H)-oxazolonium salts from amides of 2,4-dihydroxy-3,3-dimethylbutanoic acid
  作者：F. -U. Lyubke、T. P. Kosulina、V. G. Kul'nevich

  DOI：10.1007/bf00506029

  日期：1981.7
• Nu-substituted pantoyl amides
  申请人：RESEARCH CORP

  公开号：US02446615A1

  公开（公告）日：1948-08-10