5-Benzylsulfanyl-2-phenyl-4-(toluene-4-sulfonyl)-oxazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-Benzylsulfanyl-2-phenyl-4-(toluene-4-sulfonyl)-oxazole
• 英文别名: 5-Benzylsulfanyl-4-(4-methylphenyl)sulfonyl-2-phenyl-1,3-oxazole
• 化学式: C₂₃H₁₉NO₃S₂
• 分子量: 421.541
• InChiKey: PNXNKIIVIUSSPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  93.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  Benzamide, N-[2,2-dichloro-1-[(4-methylphenyl)sulfonyl]ethenyl]- 在 sodium hydrogensulfide 作用下， 以 乙醇 为溶剂， 反应 39.0h， 生成 5-Benzylsulfanyl-2-phenyl-4-(toluene-4-sulfonyl)-oxazole
  参考文献：
  名称：

  摘要：

  In reaction of excess thiols with alpha -aryisulfonyl-substituted enamides containing two chlorine atoms in P-position to the amide moiety the chlorine atoms and the arylsulfonyl group attached to the C=C bond are replaced by alkylthio or arylthio groups. The sulfur-containing enamides obtained undergo cyclization when treated with phosphorus pentachloride or thionyl chloride to furnish 4,5-dimercaptooxazoles used for preparation of the corresponding disulfonyl derivatives. The latter were also obtained by treating in succession the N-(1-arylsulfonyl-2,2-dichloroethenyl)carboxamides with sodium hydrosulfide, then with alkyl halides, and hydrogen peroxide in acetic acid.

  DOI：

  10.1023/a:1013196415680

文献信息

• ——
  作者：S. B. Babii、V. S. Zyabrev、B. S. Drach

  DOI：10.1023/a:1013196415680

  日期：——

  In reaction of excess thiols with alpha -aryisulfonyl-substituted enamides containing two chlorine atoms in P-position to the amide moiety the chlorine atoms and the arylsulfonyl group attached to the C=C bond are replaced by alkylthio or arylthio groups. The sulfur-containing enamides obtained undergo cyclization when treated with phosphorus pentachloride or thionyl chloride to furnish 4,5-dimercaptooxazoles used for preparation of the corresponding disulfonyl derivatives. The latter were also obtained by treating in succession the N-(1-arylsulfonyl-2,2-dichloroethenyl)carboxamides with sodium hydrosulfide, then with alkyl halides, and hydrogen peroxide in acetic acid.