Benzonitrile, 4-(6-chloro-3,4-dihydro-2H-1-benzopyran-2-yl)- | 135014-51-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: Benzonitrile, 4-(6-chloro-3,4-dihydro-2H-1-benzopyran-2-yl)-
• 英文别名: 4-(6-chloro-3,4-dihydro-2H-chromen-2-yl)benzonitrile
• CAS: 135014-51-6
• 化学式: C₁₆H₁₂ClNO
• 分子量: 269.72
• InChiKey: BORVVVOHURDDFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  33
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• INFLUENZA VIRUS AND TYPE 1 DIABETES
  申请人：Ospedale San Raffaele S.r.l.

  公开号：EP2906231A2

  公开（公告）日：2015-08-19
• Coxsackie B virus and type 1 diabetes
  申请人：Rappuoli Rino

  公开号：US20100047273A1

  公开（公告）日：2010-02-25

  Type 1 diabetes mellitus is characterized by loss of pancreatic insulin-producing beta cells, resulting in insulin deficiency. The usual cause of this beta cell loss is autoimmune destruction. Coxsackie virus has been detected in human pancreatic beta cells and causes insulitis. This non-destructive islet inflammation does not itself cause diabetes, but this disease will occur if viral infection is followed by a separate autoimmune response. The insulitis is mediated mainly by natural killer cells. Islets from coxsackie virus positive samples displayed reduced insulin secretion in response to glucose and other secretagogues. Virus extracted from positive islets was able to infect beta cells from human islets of non-diabetic donors, causing viral inclusions and signs of pyknosis.