2,2',2",2"'-<(2,2'-Bipyridine-6,6'-diyl)bis(methylenenitrilo)>tetrakis(acetic acid) | 94817-64-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,2',2",2"'-<(2,2'-Bipyridine-6,6'-diyl)bis(methylenenitrilo)>tetrakis(acetic acid)
• 英文别名: 2,2'-Bipyridin-6,6'-bis(methylamin-N,N-diessigsaeure)；N,N'-[[(2,2'-bipyridine)-6,6'-diyl]bis(methylene)]bis(N-carboxymethyl)glycine；2-[[6-[6-[[Bis(carboxymethyl)amino]methyl]pyridin-2-yl]pyridin-2-yl]methyl-(carboxymethyl)amino]acetic acid
• CAS: 94817-64-8
• 化学式: C₂₀H₂₂N₄O₈
• 分子量: 446.417
• InChiKey: KGOHYDSIRHJRFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5
• 重原子数：
  32
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  182
• 氢给体数：
  4
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  6,6’-双(氯甲基)-2,2’-联吡啶 在 氢氧化钾 作用下， 以 水 、 苯 为溶剂， 反应 9.0h， 生成 2,2',2",2"'-<(2,2'-Bipyridine-6,6'-diyl)bis(methylenenitrilo)>tetrakis(acetic acid)
  参考文献：
  名称：

  Ohm, Christian; Voegtle, Fritz, Chemische Berichte, 1985, vol. 118, # 1, p. 22 - 27

  摘要：

  DOI：

文献信息

• New 2,2?-Bipyridine Derivatives and Their Luminescence Properties with Europium(III) and Terbium(III) Ions
  作者：Veli-Matti Mukkala、Jouko J. Kankare

  DOI：10.1002/hlca.19920750512

  日期：1992.8.13

  Twenty differently substituted 2,2′,2″,2‴ -[(2,2′-bipyridine-6,6′-diyl)bis(methylenenitrilo)]tetrakis(acetc acids) 75–94 were synthesized with the purpose of developing new markers to be used in bioaffinity assays based on the unique luminescence properties of EuIII and TbIII ions. The relative luminescence yields, excitation maxima, and emission decay constants were determined for the corresponding

  合成了二十种不同取代的2,2'，2''，2‴-[（2,2'-联吡啶-6,6'-二基）双（亚甲基腈）]四（乙酸）75-94，用于开发基于Eu III和Tb III离子独特的发光特性，用于生物亲和力测定的新标记。确定了相应的Eu III和Tb III螯合物的相对发光产率，激发最大值和发射衰减常数。在联吡啶基的取代基对发光性能的效果显著：最好相对发光率ř用于与给电子取代基的配体，获得（例如Me，Ph），吸电子取代基（例如NO 2，COOH）具有相反的作用。然而，在相对发光产率和取代基参数之间没有发现明显的相关性。
• Bipyridil-based chelators for Gd(<scp>iii</scp>) complexation: kinetic, structural and relaxation properties
  作者：Szilvia Bunda、Norbert Lihi、Zsófia Szaniszló、David Esteban-Gómez、Carlos Platas-Iglesias、Mónika Kéri、Gábor Papp、Ferenc Krisztián Kálmán

  DOI：10.1039/d3dt02806b

  日期：——

  inertness of the Gd(III) chelates can be increased through the rigidification of the ligand structure. One of the potential ligands is (2,2′,2′′,2′′′-(([2,2′-bipyridine]-6,6′-diylbis(methylene))bis(azanetriyl))tetraacetic acid) (H4DIPTA), which has been successfully used as a fluorescent probe for lanthanides; however, it has never been considered as a potential chelator for Gd(III) ions. In this paper

  近20年来，由于肾源性系统性纤维化（NSF）疾病的出现，MRI（磁共振成像）造影剂（CA）领域的研究得到加强。NSF 与 MRI 中用作 CA的某些 Gd( III ) 基化合物的体内解离有关。为了防止静脉注射后探针的脱螯合，非常需要提高其体内稳定性。Gd( III )螯合物的惰性可以通过配体结构的刚性化来提高。潜在的配体之一是 (2,2',2'',2'''-(([2,2'-联吡啶]-6,6'-二基双(亚甲基))双(氮杂三基))四乙酸) (H 4 DIPTA)，已成功用作镧系元素的荧光探针；然而，它从未被认为是 Gd( III ) 离子的潜在螯合剂。在本文中，我们报道了 Gd( III ) 和 DIPTA 形成的配合物的热力学、动力学和结构特征。由于 [Gd(DIPTA)] -螯合物在酸性条件下的溶解度非常低，阻碍了其热力学表征，我们只能假设其稳定性接近结构类似物 [Gd(FENTA)] -
• CHELATING POLYMERS
  申请人：NYCOMED IMAGING AS

  公开号：EP0664819B1

  公开（公告）日：1997-08-06
• Novel fine fluorescent particle
  申请人：Matsumoto Kazuko

  公开号：US20070026407A1

  公开（公告）日：2007-02-01

  Novel silica particles having bondable functional groups on the surface thereof and containing a fluorescent rare-earth complex characterized by being uninfluenced by the surrounding environment including a buffer and a substance to be labeled. The silica particles containing a fluorescent rare-earth complex specifically are ones which comprise silica particles containing a fluorescent rare-earth complex selectively in an inner layer thereof and the surface of which consists substantially of silica. Also provided are: a fluorescent labeling agent comprising the silica particles; a method of fluorescent labeling which comprises using the silica particles as a labeling agent; and a method for fluorescent determination and a reagent for fluorescent determination which employ the fluorescent labeling agent.
• ACRYLIC PRESSURE-SENSITIVE ADHESIVE COMPOSITIONS
  申请人：Kim Se Ra

  公开号：US20100188620A1

  公开（公告）日：2010-07-29

  The present invention relates to an acrylic pressure-sensitive adhesive composition, and more particularly, to an acrylic pressure-sensitive adhesive composition, which comprises (a) 100 weight parts of an acrylic copolymer, (b) 0.001 to 30 weight parts of an antistatic agent; and (c) 0.01 to 10 weight parts of a corrosion inhibitor, thereby being optically transparent, causing durability and reliability not to change, and simultaneously improving antistatic performance and preventing generation of corrosion although the adhesive composition comes into contact with a metal surface.