4-[3-(3-Ethoxy-4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[3-(3-Ethoxy-4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pyridine
• 英文别名: 3-(3-ethoxy-4-methoxyphenyl)-5-pyridin-4-yl-1,2,4-oxadiazole
• 化学式: C₁₆H₁₅N₃O₃
• mdl: MFCD06595070
• 分子量: 297.31
• InChiKey: ALQJLKRMSQNIBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  70.3
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Modulators of sphingosine phosphate receptors
  申请人：The Scripps Research Institute

  公开号：US10544136B2

  公开（公告）日：2020-01-28

  Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphinogosine-1-phosphate receptor subtype 3. Uses and methods of inventive compounds for treatment of malconditions wherein activation, agonism, inhibition or antagonism of the S1P1 is medically indicated are provided.

  本研究提供了能激活亚型 1 的鞘氨醇-1-磷酸受体的化合物。与鞘氨醇-1-磷酸受体亚型 3 相比，某些化合物可选择性地激活受体亚型 1。本发明提供了本发明化合物的用途和方法，用于治疗S1P1的活化、激动、抑制或拮抗在医学上适用的不良病症。
• NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS
  申请人：The Scripps Research Institute

  公开号：US20180009770A1

  公开（公告）日：2018-01-11

  Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphingosine-1-phosphate receptor subtype 3. Uses and methods of inventive compounds for treatment of malconditions wherein activation, agonism, inhibition or antagonism of the S1P1 is medically indicated are provided.
• US9975863B2
  申请人：——

  公开号：US9975863B2

  公开（公告）日：2018-05-22