6,6-dimethyl-1-phenyl-6,7-dihydro-1H-indol-4(5H)-one | 459783-90-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 6,6-dimethyl-1-phenyl-6,7-dihydro-1H-indol-4(5H)-one
• 英文别名: 6,6-dimethyl-1-phenyl-6,7-dihydro-1H-indole-4(5H)one；6,6-Dimethyl-1-phenyl-5,7-dihydroindol-4-one
• CAS: 459783-90-5
• 化学式: C₁₆H₁₇NO
• 分子量: 239.317
• InChiKey: MIDDLHDCELXZET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  22
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  苯胺 、 2-ethoxy-6,6-dimethyl-2,3,6,7-tetrahydrobenzofuran-4(5H)-one 在 对甲苯磺酸 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 反应 18.0h， 生成 6,6-dimethyl-1-phenyl-6,7-dihydro-1H-indol-4(5H)-one
  参考文献：
  名称：

  KR2016/20022

  摘要：

  公开号：

文献信息

• KR2016/20022
  申请人：——

  公开号：——

  公开（公告）日：——
• Efficient One-Pot Synthesis of Multi-Substituted Dihydrofurans by Ruthenium(II)-Catalyzed [3+2] Cycloaddition of Cyclic or Acyclic Diazodicarbonyl Compounds with Olefins
  作者：Likai Xia、Yong Rok Lee

  DOI：10.1002/adsc.201300245

  日期：2013.8.12

  AbstractRuthenium(II)‐phosphine complexes‐catalyzed [3+2] cycloadditions were conducted to synthesize a variety of dihydrofurans by reactions of cyclic or acyclic diazodicarbonyl compounds with olefins. This method represents a direct and efficient one‐pot synthesis for multi‐substituted dihydrofurans under mild reaction conditions with an excellent regioselectivity. Furthermore, to reduce reaction times and increase yields of dihydrofurans, microwave‐assisted tris(triphenylphosphine)ruthenium(II) chloride/ 1‐butyl‐3‐methylimidazolium tetrafluoroborate Ru(PPh3)3Cl2/[Bmim]BF4}‐catalyzed reactions were also developed. The synthesized dihydrofurans can be readily converted into biologically interesting tetrahydroindoles.magnified image