(2R,3R)-3,4',7-trihydroxy-3'-prenylflavane

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: (2R,3R)-3,4',7-trihydroxy-3'-prenylflavane
• 英文别名: (2R,3R)-2-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]-3,4-dihydro-2H-chromene-3,7-diol
• 化学式: C₂₀H₂₂O₄
• 分子量: 326.4
• InChiKey: PTZNBCJWCJFLPQ-UYAOXDASSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  69.9
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• ANDROGRAPHIS PANICULATA COMPOSITIONS AND METHODS FOR TREATMENT OF ADDICTIONS
  申请人：Omeros Corporation

  公开号：EP2866817A2

  公开（公告）日：2015-05-06
• Andrographis Paniculata Compositions and Methods for Treatment of Addictions
  申请人：Omeros Corporation

  公开号：US20140072662A1

  公开（公告）日：2014-03-13

  Methods and compositions for the treatment or prevention of addictions and impulse control disorders using Andrographis paniculata , active substances contained therein and extracts thereof, alone or in combination with other therapeutic agents. The methods and compositions of the invention are useful in the treatment or prevention of addiction to substances, including alcohol, nicotine, marijuana, opioid agonists cocaine, and amphetamines, as well as impulse control disorders, including pathological gambling and pathological overeating.
• [EN] ANDROGRAPHIS PANICULATA COMPOSITIONS AND METHODS FOR TREATMENT OF ADDICTIONS<br/>[FR] COMPOSITIONS D'ANDROGRAPHIS PANICULATA ET PROCÉDÉS DE TRAITEMENT D'ADDICTIONS
  申请人：OMEROS CORP

  公开号：WO2014008351A2

  公开（公告）日：2014-01-09

  Methods and compositions for the treatment or prevention of addictions and impulse control disorders using Andrographis paniculata, active substances contained therein and extracts thereof, alone or in combination with other therapeutic agents. The methods and compositions of the invention are useful in the treatment or prevention of addiction to substances, including alcohol, nicotine, marijuana, opioid agonists cocaine, and amphetamines, as well as impulse control disorders, including pathological gambling and pathological overeating.
• [EN] COMPOSITIONS AND METHODS FOR TREATMENT OF INFLAMMATION WITH STEROIDS AND A MODULATOR<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DE L'INFLAMMATION AVEC DES STÉROÏDES ET UN MODULATEUR
  申请人：BUZZELET DEVELOPMENT AND TECHNOLOGIES LTD

  公开号：WO2021117016A1

  公开（公告）日：2021-06-17

  Provided are pharmaceutical compositions comprising a pharmaceutically effective amount of a steroid and a pharmaceutically effective amount of at least one modulator selected from the group consisting of a transient receptor poteintial (TRP) channel modulator and a proliferatior-activated receptor (PRP) modulator, wherein cannabidiol is not present as the sole modulator, and uses thereof for treating a condition or a symptom thereof, wherein said condition involves inflammation, an immune disease, an autoimmune disease or a combination thereof.