[5-(2-Methylbut-3-yn-2-yl)-2-(4-methylphenyl)pyrazol-3-yl]carbamic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [5-(2-Methylbut-3-yn-2-yl)-2-(4-methylphenyl)pyrazol-3-yl]carbamic acid
• 英文别名: [5-(2-methylbut-3-yn-2-yl)-2-(4-methylphenyl)pyrazol-3-yl]carbamic acid
• 化学式: C₁₆H₁₇N₃O₂
• 分子量: 283.32
• InChiKey: JSIVHTNURLNPKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  67.2
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• KINASE INHIBITORS
  申请人：RESPIVERT LIMITED

  公开号：US20150225373A1

  公开（公告）日：2015-08-13

  There are provided compounds of formula (I), wherein R 1 to R 5 , X 1 , X 2 , Ar, L, E, A, A 1 , G and G 1 have meanings given in the description, which compounds have anti-inflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

  提供了化合物的公式(I)，其中R1到R5、X1、X2、Ar、L、E、A、A1、G和G1的含义在说明中给出，这些化合物具有抗炎活性（例如通过抑制p38丝裂原活化蛋白激酶酶家族之一或多个成员、Syk激酶以及酪氨酸激酶Src家族的成员之一或多个成员）并可用于治疗，包括在药物组合中，特别是用于治疗炎症性疾病，包括肺部、眼部和肠道的炎症性疾病。
• US9790209B2
  申请人：——

  公开号：US9790209B2

  公开（公告）日：2017-10-17
• [EN] KINASE INHIBITORS<br/>[FR] INHIBITEURS DE KINASE
  申请人：RESPIVERT LTD

  公开号：WO2014033447A2

  公开（公告）日：2014-03-06

  There are provided compounds of formula (I), (Formula (I)) wherein R1 to R5, X1, X2, Ar, L, E, A, A1, G and G1 have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.