1-[5-Tert-butyl-2-(4-dimethylphosphorylphenyl)pyrazol-3-yl]-3-[4-[2-(4-propylsulfanylanilino)pyrimidin-4-yl]oxynaphthalen-1-yl]urea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-[5-Tert-butyl-2-(4-dimethylphosphorylphenyl)pyrazol-3-yl]-3-[4-[2-(4-propylsulfanylanilino)pyrimidin-4-yl]oxynaphthalen-1-yl]urea
• 英文别名: 1-[5-tert-butyl-2-(4-dimethylphosphorylphenyl)pyrazol-3-yl]-3-[4-[2-(4-propylsulfanylanilino)pyrimidin-4-yl]oxynaphthalen-1-yl]urea
• 化学式: C₃₉H₄₂N₇O₃PS
• 分子量: 719.8
• InChiKey: WUTZDWDHRSIPRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  51
• 可旋转键数：
  12
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  148
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• [EN] KINASE INHIBITORS<br/>[FR] INHIBITEURS DE KINASES
  申请人：RESPIVERT LTD

  公开号：WO2014033446A1

  公开（公告）日：2014-03-06

  There are provided compounds of formula (I), (Formula (I)) wherein R1 to R5, X1, X2, Ar, L, A, A1, E and G have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.