(3aS,4S,6R,6aR)-tert-butyl 4-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-6-(((2-((tert-butoxycarbonyl)amino)-3-methylbutanoyl)oxy)methyl)-2,2-dimethyldihydro-3aH-[1,3]dioxolo[4,5-c]pyrrole-5(4H)-carboxylate 、
三氯化硼 在
溶剂黄146 、
水 作用下,
以
三氟乙酸 为溶剂,
反应 1.07h,
以to afford (S)-((2R,3R,4S,5S)-5-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-3,4-dihydroxypyrrolidin-2-yl)methyl 2-amino-3-methylbutanoate Hydrochloride (30f) (400 mg, 76%) as a white solid的产率得到(S)-((2R,3R,4S,5S)-5-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-3,4-dihydroxypyrrolidin-2-yl)methyl 2-amino-3-methylbutanoate Hydrochloride