2-(2-methoxyethylsulfanyl)-5,5-dimethyl-3-[[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]methyl]-6H-benzo[h]quinazolin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(2-methoxyethylsulfanyl)-5,5-dimethyl-3-[[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]methyl]-6H-benzo[h]quinazolin-4-one
• 化学式: C₂₇H₂₈N₄O₃S
• 分子量: 488.6
• InChiKey: QBYXQKCBSGYGPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  106
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• METHODS AND COMPOSITIONS FOR TREATING BACTERIAL INFECTION
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US20150132352A1

  公开（公告）日：2015-05-14

  The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides compounds as therapeutic agents against bacterial infections (e.g., biofilms).

  本发明涉及化学化合物，它们的发现方法，以及它们的治疗和研究用途。具体而言，本发明提供了作为治疗剂抗击细菌感染（例如生物膜）的化合物。
• Methods and compositions for treating bacterial infection
  申请人：Curators of the University of Missouri

  公开号：US10441588B2

  公开（公告）日：2019-10-15

  The present disclosure relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present disclosure provides compounds as therapeutic agents against bacterial infections (e.g., biofilms). The present disclosure also provides topical formulations for use in methods for treating bacterial infections.

  本公开涉及化合物、发现化合物的方法及其治疗和研究用途。特别是，本公开内容提供了作为治疗剂的化合物，用于对抗细菌感染（如生物膜）。本公开还提供了用于治疗细菌感染方法的局部制剂。
• US9504688B2
  申请人：——

  公开号：US9504688B2

  公开（公告）日：2016-11-29
• US9814719B2
  申请人：——

  公开号：US9814719B2

  公开（公告）日：2017-11-14
• [EN] METHODS AND COMPOSITIONS FOR TREATING BACTERIAL INFECTION<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR TRAITER UNE INFECTION BACTÉRIENNE
  申请人：UNIV MICHIGAN

  公开号：WO2013166282A2

  公开（公告）日：2013-11-07

  The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides compounds as therapeutic agents against bacterial infections (e.g., biofilms).