7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one;(3S)-3-(3,3-dimethylbutylamino)-4-[[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one;(3S)-3-(3,3-dimethylbutylamino)-4-[[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid
• 化学式: C48H64N2O20
• 分子量: 989.0
• InChiKey: FFFYRMDWZXFEJM-ZAJGVABRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  70
• 可旋转键数：
  19
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  339
• 氢给体数：
  11
• 氢受体数：
  21

文献信息

• [EN] TASTE MASKED PHARMACEUTICAL COMPOSITIONS<br/>[FR] COMPOSITIONS PHARMACEUTIQUES AU GOÛT MASQUÉ
  申请人：VB MEDICARE PVT LTD

  公开号：WO2013175511A1

  公开（公告）日：2013-11-28

  This invention comprises an unpleasant-taste-masked pharmaceutical composition for oral consumption comprising at least one pharmaceutical active compound of unpleasant taste; the said pharmaceutical composition comprising an agglomerate of the pharmaceutically active compound/s, at least one sweetener and optionally one or more of diluents/bulking agents, excipients/adjuvents and flavors. In one embodiment of the unpleasant-taste-masked pharmaceutical composition, the sweetener in the agglomerate comprises at least a high intensity sweetener; or a mixture of one or more of low intensity sweetener and at least one high intensity sweetener. An embodiment of the unpleasant-taste-masked pharmaceutical composition may further comprise a coating of a water insoluble material on the agglomerate wherein the thickness of the coating is strong enough to prevent release of unpleasant taste on tongue when orally administered but release more than 80% of the pharmaceutically active unpleasant tasting compound in 15 minutes when subjected to dissolution in Phosphate buffer pH 5.8 media using USP Type 2 apparatus. The unpleasant-taste-masked pharmaceutical composition of this invention may further comprise at least one thickener in the agglomerate. The unpleasant-taste-masked pharmaceutical composition of this invention may also comprise at least one binding agent in the agglomerate or/and may also comprise effervescence generating means. In the context of this invention, unpleasant taste comprises bitter taste and any other taste that is repulsive for oral consumption. The pharmaceutical composition of this invention may be an orodispersible or water dispersible composition. The invention also comprises methods of making the compositions of this invention.