(2R)-6,8-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: (2R)-6,8-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one
• 化学式: C₁₅H₁₂O₇
• 分子量: 304.25
• InChiKey: AYZWVFDFNWNUSS-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  127
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• RECOMBINANT HOST CELLS WITH IMPROVED PRODUCTION OF TETRAKETIDE DERIVATIVES
  申请人：Barrit Sarl

  公开号：EP3906301A1

  公开（公告）日：2021-11-10
• [EN] DIHYDROMYRICETIN FOR THE TREATMENT OF DISEASES AND DISORDERS OF THE GLUTAMATERGIC SYSTEM<br/>[FR] DIHYDROMYRICÉTINE POUR LE TRAITEMENT DE MALADIES ET DE TROUBLES DU SYSTÈME GLUTAMATERGIQUE
  申请人：UNIV CALIFORNIA

  公开号：WO2014007853A1

  公开（公告）日：2014-01-09

  Disclosed herein are methods and compositions for treating a disease or disorder of the glutamatergic system, e.g., Alzheimer's disease, neuron damage and/or loss, and seizures, or a symptom thereof, e.g., decreased cognitive function, in a subject which comprises administering dihydromyricetin (DHM), an analog of DHM, or a metabolite of DHM to the subject.
• [EN] RECOMBINANT HOST CELLS WITH IMPROVED PRODUCTION OF TETRAKETIDE DERIVATIVES<br/>[FR] CELLULES HÔTES RECOMBINANTES À PRODUCTION AMÉLIORÉE DE DÉRIVÉS DE TETRAKETIDE
  申请人：BARRIT SARL

  公开号：WO2020141230A1

  公开（公告）日：2020-07-09

  The present invention relates to arecombinant microbial host cell producing a tetraketide or derivatives thereof from one or more substrates selected from cinnamoyl-CoA, p-Coumaroyl-CoA, Caffeoyl-CoA, Feruloyl-CoA, malonyl-CoA, sinapoyl-CoA and dihydro derivatives thereof, comprising an operative biosynthetic metabolic pathway for the tetraketide or derivatives thereof comprising a chalcone isomerase-like (CHIL) polypeptide heterologous to the host cell and a Type 3 polyketide synthase (PKS).