[1-[(3S)-3,7-dimethyloct-6-enoxy]-2-[4-(1,3-oxazol-2-yl)phenyl]-1-phosphanylethyl]phosphane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [1-[(3S)-3,7-dimethyloct-6-enoxy]-2-[4-(1,3-oxazol-2-yl)phenyl]-1-phosphanylethyl]phosphane
• 化学式: C₂₁H₃₁NO₂P₂
• 分子量: 391.4
• InChiKey: SEOSGJNBHBIWPH-KRWDZBQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  26
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  35.3
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] THERAPEUTIC BISPHOSPHONATES<br/>[FR] BISPHOSPHONATES THÉRAPEUTIQUES
  申请人：UNIV IOWA RES FOUND

  公开号：WO2014008407A1

  公开（公告）日：2014-01-09

  The invention provides novel pyrophosphate synthase inhibitors of formula I and formula II as well salts thereof; the invention also provides compositions comprising such inhibitors and methods for their use.

  本发明提供了新颖的焦磷酸合成酶抑制剂，其化学式为I和II以及它们的盐；本发明还提供了包含这些抑制剂的组合物及其使用方法。
• [EN] METHODS TO MODULATE RAC1 IMPORT AND TO TREAT PULMONARY FIBROSIS<br/>[FR] PROCÉDÉS POUR MODULER L'APPORT DE RAC1 ET POUR TRAITER LA FIBROSE PULMONAIRE
  申请人：UNIV IOWA RES FOUND

  公开号：WO2014176546A1

  公开（公告）日：2014-10-30

  The invention provides methods for treating fibrosis, as well as methods for modulating mitochondrial peroxide production in a cell, and methods for modulating the import of Rac I into the mitochondria of a cell, comprising contacting the cell with an effective amount of a geranylgeranyl pyrophosphate (GGPP) synthase inhibitor or a pharmaceutically acceptable salt or prodrug thereof.