2-[[2-[[4-cyclopropyl-5-(2-fluorophenyl)-1,2,4-triazol-3-yl]sulfanyl]acetyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[[2-[[4-cyclopropyl-5-(2-fluorophenyl)-1,2,4-triazol-3-yl]sulfanyl]acetyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
• 化学式: C₂₁H₂₀FN₅O₂S₂
• 分子量: 457.5
• InChiKey: UYBVBGZFQDXNED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  156
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Small molecule regulators of mitochondrial fusion and methods of use thereof
  申请人：Washington University

  公开号：US10844023B2

  公开（公告）日：2020-11-24

  Compositions comprising small molecule mitofusin agonists are described. The mitofusin modulating agents are useful for treating diseases or disorders associated with a mitochondria-associated disease, disorder, or condition such as diseases or disorders associated with mitofusin 1 (Mfn1) and/or mitofusin 2 (Mfn2), or mitochondrial dysfunction. Methods of treatment, pharmaceutical formulations, and screening methods for identifying compounds that regulate mitochondrial function are also described.

  本文描述了包含小分子丝裂霉素激动剂的组合物。丝裂素素调节剂可用于治疗与线粒体相关的疾病、紊乱或病症，如与丝裂素素1（Mfn1）和/或丝裂素素2（Mfn2）或线粒体功能障碍相关的疾病或紊乱。还描述了治疗方法、药物制剂和用于鉴定调节线粒体功能的化合物的筛选方法。
• SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF
  申请人：Wahington University

  公开号：US20190169138A1

  公开（公告）日：2019-06-06

  Compositions comprising small molecule mitofusin agonists are described. The mitofusin modulating agents are useful for treating diseases or disorders associated with a mitochondria-associated disease, disorder, or condition such as diseases or disorders associated with mitofusin 1 (Mfn1) and/or mitofusin 2 (Mfn2), or mitochondrial dysfunction. Methods of treatment, pharmaceutical formulations, and screening methods for identifying compounds that regulate mitochondrial function are also described.