pentaerythritol tetrakis(3-(S-(1-methoxycarbonylethyl)trithiocarbonyl)propionate) | 1190289-66-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: pentaerythritol tetrakis(3-(S-(1-methoxycarbonylethyl)trithiocarbonyl)propionate)
• 英文别名: Methyl 2-[3-[3-[3-(1-methoxy-1-oxopropan-2-yl)sulfanylcarbothioylsulfanylpropanoyloxy]-2,2-bis[3-(1-methoxy-1-oxopropan-2-yl)sulfanylcarbothioylsulfanylpropanoyloxymethyl]propoxy]-3-oxopropyl]sulfanylcarbothioylsulfanylpropanoate；methyl 2-[3-[3-[3-(1-methoxy-1-oxopropan-2-yl)sulfanylcarbothioylsulfanylpropanoyloxy]-2,2-bis[3-(1-methoxy-1-oxopropan-2-yl)sulfanylcarbothioylsulfanylpropanoyloxymethyl]propoxy]-3-oxopropyl]sulfanylcarbothioylsulfanylpropanoate
• CAS: 1190289-66-7
• 化学式: C₃₇H₅₂O₁₆S₁₂
• 分子量: 1137.6
• InChiKey: WMSCDBWEFHSKGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  65
• 可旋转键数：
  44
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  541
• 氢给体数：
  0
• 氢受体数：
  28

反应信息

• 作为产物：
  描述：

  二硫化碳 、 2-溴丙酸甲酯 、 四(3-巯基丙酸)季戊四醇酯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以88%的产率得到pentaerythritol tetrakis(3-(S-(1-methoxycarbonylethyl)trithiocarbonyl)propionate)
  参考文献：
  名称：

  Highly Protein-Resistant Coatings and Suspension Cell Culture Thereon from Amphiphilic Block Copolymers Prepared by RAFT Polymerization

  摘要：

  Novel amphiphilic block copolymers composed of hydrophobic (poly(2-methoxyethyl acrylate): M) and hydrophilic (poly(N,N-dimethylacrylamide): D) segments were synthesized by living radical polymerization: a reversible addition-fragmentation chain-transfer polymerization. Two types of amphiphilic block copolymers, triblock (MDM) and 4-arm block ((MD)4) copolymers with specific compositions (D/M = (750-1500)/250), were prepared by a versatile one-pot synthesis. These copolymers show good adhesion to various types of substrates (e.g., polystyrene, polycarbonate, polypropylene, Ti, and glass), and the surface coating showed high protein repellency and a low contact angle for water, regardless of the substrate. The two opposing characteristics of high protein repellency and good substrate adhesion were achieved by the combined effects of the molecular architecture of the block copolymers, the high molecular weight, and the characteristics of each segment, that is, low protein adsorption capability of both segments and low glass transition temperature of the hydrophobic segment. Further, a polystyrene dish coated with the MDM block copolymer could be sterilized by γ-ray irradiation and used as a good substrate for a suspension cell culture that exhibits low cell adhesion and good cell growth.

  DOI：

  10.1021/bm401914c

文献信息

• Highly Protein-Resistant Coatings and Suspension Cell Culture Thereon from Amphiphilic Block Copolymers Prepared by RAFT Polymerization
  作者：Kazutoshi Haraguchi、Kazuomi Kubota、Tetsuo Takada、Saori Mahara

  DOI：10.1021/bm401914c

  日期：2014.6.9

  Novel amphiphilic block copolymers composed of hydrophobic (poly(2-methoxyethyl acrylate): M) and hydrophilic (poly(N,N-dimethylacrylamide): D) segments were synthesized by living radical polymerization: a reversible addition-fragmentation chain-transfer polymerization. Two types of amphiphilic block copolymers, triblock (MDM) and 4-arm block ((MD)4) copolymers with specific compositions (D/M = (750-1500)/250), were prepared by a versatile one-pot synthesis. These copolymers show good adhesion to various types of substrates (e.g., polystyrene, polycarbonate, polypropylene, Ti, and glass), and the surface coating showed high protein repellency and a low contact angle for water, regardless of the substrate. The two opposing characteristics of high protein repellency and good substrate adhesion were achieved by the combined effects of the molecular architecture of the block copolymers, the high molecular weight, and the characteristics of each segment, that is, low protein adsorption capability of both segments and low glass transition temperature of the hydrophobic segment. Further, a polystyrene dish coated with the MDM block copolymer could be sterilized by γ-ray irradiation and used as a good substrate for a suspension cell culture that exhibits low cell adhesion and good cell growth.