(4-methylthiophenyl)[4-(2,3-epoxypropyloxy)phenyl](naphth-1-yl)methane | 1143581-00-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (4-methylthiophenyl)[4-(2,3-epoxypropyloxy)phenyl](naphth-1-yl)methane
• 英文别名: (4-Methylthiophenyl)[4-(2,3-epoxypropyloxy)phenyl]-(naphth-1-yl)methane；2-[[4-[(4-methylsulfanylphenyl)-naphthalen-1-ylmethyl]phenoxy]methyl]oxirane
• CAS: 1143581-00-3
• 化学式: C₂₇H₂₄O₂S
• 分子量: 412.552
• InChiKey: VNTPXSLWUHBUEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  47.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (4-methylthiophenyl)[4-(2,3-epoxypropyloxy)phenyl](naphth-1-yl)methane 、 二乙胺 以 乙醇 为溶剂， 生成 (4-methylthiophenyl)[4-(2-hydroxy-3-diethylaminopropyloxy)phenyl](naphth-1-yl)methane
  参考文献：
  名称：

  Thiol derivatives of arylnaphthylmethane as novel anti-osteoporotic agents

  摘要：

  (Mercaptophenyl)naphthylmethane derivatives were synthesized as novel estrogen receptor binding ligands. [4-(Methylsulfonyl)phenyl](naphth-1-yl)ketone shows a very promising activity towards osteoporosis.

  DOI：

  10.1007/s00706-007-0848-2
• 作为产物：
  描述：

  (4-methylthiophenyl)(4-hydroxyphenyl)(naphth-1-yl)methane 、 环氧氯丙烷 在 potassium carbonate 作用下， 反应 10.0h， 以95.05%的产率得到(4-methylthiophenyl)[4-(2,3-epoxypropyloxy)phenyl](naphth-1-yl)methane
  参考文献：
  名称：

  Thiol derivatives of arylnaphthylmethane as novel anti-osteoporotic agents

  摘要：

  (Mercaptophenyl)naphthylmethane derivatives were synthesized as novel estrogen receptor binding ligands. [4-(Methylsulfonyl)phenyl](naphth-1-yl)ketone shows a very promising activity towards osteoporosis.

  DOI：

  10.1007/s00706-007-0848-2

文献信息

• Thiol derivatives of arylnaphthylmethane as novel anti-osteoporotic agents
  作者：Sangita、Atul Kumar、Shikha Sharma、Surojeet Sengupta、Man Mohan Singh、Suprabhat Ray

  DOI：10.1007/s00706-007-0848-2

  日期：2008.10

  (Mercaptophenyl)naphthylmethane derivatives were synthesized as novel estrogen receptor binding ligands. [4-(Methylsulfonyl)phenyl](naphth-1-yl)ketone shows a very promising activity towards osteoporosis.