4-[1-[2,4-dimethyl-5-[4-methyl-3-(trifluoromethoxy)-1H-pyrazol-5-yl]benzoyl]azetidin-3-yl]benzonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[1-[2,4-dimethyl-5-[4-methyl-3-(trifluoromethoxy)-1H-pyrazol-5-yl]benzoyl]azetidin-3-yl]benzonitrile
• 化学式: C₂₄H₂₁F₃N₄O₂
• 分子量: 454.4
• InChiKey: OMIAHVDXCCZLJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  82
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS AND COMBINATIONS THEREOF<br/>[FR] MODULATEURS HÉTÉROCYCLIQUES DE LA SYNTHÈSE DES LIPIDES ET COMBINAISONS EN CONTENANT
  申请人：3 V BIOSCIENCES INC

  公开号：WO2015095767A1

  公开（公告）日：2015-06-25

  Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

  提供了杂环调节剂脂质合成以及其药用盐；包括这些化合物的药物组合物；以及通过给予这些化合物和其他治疗剂的组合来治疗脂肪酸合酶途径失调症状的方法。
• [EN] HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS<br/>[FR] MODULATEURS HÉTÉROCYCLIQUES DE LA SYNTHÈSE DES LIPIDES
  申请人：3 V BIOSCIENCES INC

  公开号：WO2014008197A1

  公开（公告）日：2014-01-09

  Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.

  提供了异环调节脂质合成的调节剂及其药用盐；包括这些化合物的药物组合物；以及通过给予这些化合物来治疗由于脂肪酸合酶途径失调而表现出的疾病的方法。
• HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS
  申请人：3-V Biosciences, Inc.

  公开号：US20150210688A1

  公开（公告）日：2015-07-30

  Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.

  提供异环丙基脂质合成调节剂及其药学上可接受的盐；包含这些化合物的药物组合物；以及通过给予这些化合物治疗脂肪酸合酶途径调节失常所表现出的病症的方法。
• Heterocyclic modulators of lipid synthesis
  申请人：Sagimet Biosciences Inc.

  公开号：US11034690B2

  公开（公告）日：2021-06-15

  Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

  本研究提供了脂肪酸合成调节剂化合物。通过调节脂肪酸合成酶的功能和/或脂肪酸合成酶途径，这些化合物可用于治疗以脂肪酸合成酶功能失调为特征的疾病。提供了治疗此类疾病的方法，包括病毒感染，如丙型肝炎感染、癌症和代谢紊乱，如非酒精性脂肪性肝炎（NASH）。
• HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS AND COMBINATIONS THEREOF
  申请人：Sagimet Biosciences Inc.

  公开号：EP3083583B1

  公开（公告）日：2020-11-18