3(R)-<(methylsulfonyl)oxy>thiolane | 126688-45-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 3(R)-<(methylsulfonyl)oxy>thiolane
• 英文别名: (R)-3-[(methanesulfonyl)oxy]tetrahydrothiophene；(R)-tetrahydrothiophen-3-yl methanesulfonate；(R)-3-Thiolanyl Methanesulfonate；[(3R)-thiolan-3-yl] methanesulfonate
• CAS: 126688-45-7
• 化学式: C₅H₁₀O₃S₂
• 分子量: 182.265
• InChiKey: CMCJGROFOLESTP-RXMQYKEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  77
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3(R)-<(methylsulfonyl)oxy>thiolane 在 peracid 作用下， 生成 3R-(Methanesulfonyloxy)thiolane 1R-oxide
  参考文献：
  名称：

  Synthesis of optically active 3(R)-[(alkylsulfonyl)oxy]thiolanes from 2(R)-hydroxy-4-(methylthio)butanoic acid or D-methionine

  摘要：

  DOI：

  10.1021/jo00298a057
• 作为产物：
  描述：

  [(3R)-1-methyl-1-methylsulfonyloxythiolan-3-yl] methanesulfonate 生成 3(R)-<(methylsulfonyl)oxy>thiolane
  参考文献：
  名称：

  URBAN, FRANK J.;BREITENBACH, RALPH;VINCENT, LAWRENCE A., J. ORG. CHEM., 55,(1990) N1, C. 3670-3672

  摘要：

  DOI：

文献信息

• ANTI-INFLAMMATORY COMPOUND, AND PREPARATION AND USE THEREOF
  申请人：VivaVision Biotech, Inc.

  公开号：US20200377460A1

  公开（公告）日：2020-12-03

  The present invention provides an anti-inflammatory compound, which is a compound having a structure (I) as shown below: The compound is a target that is important for autoimmune activation, and that has strong inhibitory effect on PDE4 and penetrates the skin easily, and is a new type anti-inflammatory compound that is easily degraded.

  本发明提供一种抗炎化合物，该化合物具有如下所示的结构（I）： 该化合物是一个重要的自身免疫激活靶点，对PDE4具有强烈的抑制作用，易于渗透皮肤，并且是一种易于降解的新型抗炎化合物。
• Enantiomeric purity enrichment of (R)-tetrahydrothiophene-3-ol sulfonyl derivatives by crystallization
  作者：Kaname Konuki、Hazuki Nagai

  DOI：10.1016/j.tetasy.2014.10.020

  日期：2014.12

  (R)-Tetrahydrothiophene-3-ol sulfonyl derivatives 3-19 were prepared by introduction of various sulfonyl groups at the hydroxyl group of (R)-tetrahydrothiophene-3-ol 1 with low enantiomeric purity (68-74% ee). Crystallization was applied to improve their enantiomeric purity. Improvement in enantiomeric purity depended on the introduced sulfonyl group. The enantiomeric purity of enantiomeric sulfonyl derivatives was improved to more than 90% ee by simple crystallization without using seed crystals. These products from crystallization provided not only higher %ee crystals but also a higher %ee mother liquor. The enantiomeric purity of diastereomeric sulfonyl derivatives was improved remarkably, and the product of the derivative 18 provided the mother liquor with 100% de. Crystallization of these sulfonyl derivatives showed a novel and interesting feature that mother liquors with high enantiomeric purity were obtained in many cases. (C) 2014 Elsevier Ltd. All rights reserved.
• VOLKMANN, ROBERT A.
  作者：VOLKMANN, ROBERT A.

  DOI：——

  日期：——
• URBAN, FRANK J.
  作者：URBAN, FRANK J.

  DOI：——

  日期：——
• URBAN, FRANK J.;BREITENBACH, RALPH;VINCENT, LAWRENCE A., J. ORG. CHEM., 55,(1990) N1, C. 3670-3672
  作者：URBAN, FRANK J.、BREITENBACH, RALPH、VINCENT, LAWRENCE A.

  DOI：——

  日期：——