3,5,7-Trihydroxy-2-(4-hydroxyphenyl)chromen-4-one;3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)chromen-4-one;3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one
• 英文别名: 3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one;3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one
• 化学式: C30H20O14
• 分子量: 604.5
• InChiKey: OBKXHQVBNHJFOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.98
• 重原子数：
  44
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  255
• 氢给体数：
  10
• 氢受体数：
  14

文献信息

• TIGHT JUNCTIONS MODULATORS
  申请人：O'neill Catherine Anne

  公开号：US20140086977A1

  公开（公告）日：2014-03-27

  The present invention relates to a new therapy targeted at the restoration or improvement of tight junction function. Aberrant TJ function, is characteristic of many chronic skin diseases. The inventors demonstrated that plant polyphenols or flavonoids and Cis-urocanic acid modulates tight junction structure and function in mammalian keratinocytes and provided tight junction modulators, pharmaceutical compositions and methods for preventing or treating impaired tight junction function in stratified mammalian epithelia.