2,3,4,4a,5,6-hexahydro-1H-isoquinolino[2,1-b]isoquinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢异喹啉
• 英文名称: 2,3,4,4a,5,6-hexahydro-1H-isoquinolino[2,1-b]isoquinoline
• 化学式: C₁₇H₁₉N
• 分子量: 237.34
• InChiKey: SAOSTKFVIBNCIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• HEXAHYDRODIBENZO[A,G]QUINOLIZINE COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF
  申请人：Shanghai Institute of Materia Medica, Chinese Academy of Sciences

  公开号：US20140088130A1

  公开（公告）日：2014-03-27

  The present invention relates to a novel hexahydrodibenzo[a,g]quinoline compound represented by general formula (I) and its derivatives, enantiomer, diastereoisomer, raceme and mixtures thereof, as well as pharmaceutically acceptable salts thereof. The present invention further relates to a method for preparing the compound, and the compound has good prevention and treatment effect on neurological diseases, especially diseases associated with dopamine receptor and 5-hydroxytryptamine receptor. The bioactivity experiment demonstrates that, the compound is expected to be developed into a novel and potent chemical entity for treating diseases associated with dopamine receptor and 5-hydroxytryptamine receptor, especially schizophrenia, Parkinson's disease, drug addiction, migraine and so on.

  本发明涉及一种由通式（I）表示的新型六氢二苯并[a,g]喹啉化合物及其衍生物、对映体、非对映体异构体、混合物以及其药学上可接受的盐。本发明还涉及一种制备该化合物的方法，该化合物对神经系统疾病具有良好的预防和治疗效果，特别是与多巴胺受体和5-羟色胺受体相关的疾病。生物活性实验证明，该化合物有望被开发成一种新型和有效的化学实体，用于治疗与多巴胺受体和5-羟色胺受体相关的疾病，特别是精神分裂症、帕金森病、药物成瘾、偏头痛等疾病。
• PHARMACEUTICAL USE OF HEXAHYDRO-DIBENZO[A,G]QUINOLIZINE COMPOUNDS
  申请人：Shanghai Institute of Materia Medica, Chinese Academy of Sciences

  公开号：EP2992883A1

  公开（公告）日：2016-03-09

  Use of hexahydro-dibenzo[a,g]quinolizine compounds as shown in formula(I) in preparing a medicine for treating and/or preventing benign prostate hyperplasia diseases.

  如式(I)所示六氢-二苯并[a,g]喹嗪化合物在制备治疗和/或预防良性前列腺增生疾病药物中的用途。
• [EN] PHARMACEUTICAL USE OF HEXAHYDRO-DIBENZO[A,G]QUINOLIZINE COMPOUNDS<br/>[FR] UTILISATION PHARMACEUTIQUE DE COMPOSÉS HEXAHYDRO-DIBENZO[A,G]QUINOLIZINE
  申请人：SHANGHAI INST MATERIA MEDICA

  公开号：WO2014177065A1

  公开（公告）日：2014-11-06

  如通式（I）所示的六氢二苯并［a,g］喹嗪类化合物在制备治疗和/或预防良性前列腺增生疾病的药物中的用途。
• US9359372B2
  申请人：——

  公开号：US9359372B2

  公开（公告）日：2016-06-07
• US9737517B2
  申请人：——

  公开号：US9737517B2

  公开（公告）日：2017-08-22