N-(3-acetamidopropyl)-N-cyclohexyl-4-(2,6-dichlorophenyl)-5-oxotetrazole-1-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(3-acetamidopropyl)-N-cyclohexyl-4-(2,6-dichlorophenyl)-5-oxotetrazole-1-carboxamide
• 化学式: C₁₉H₂₄Cl₂N₆O₃
• 分子量: 455.3
• InChiKey: LBJWOKSXBKGRLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  97.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• TETRAZOLONES AS INHIBITORS OF FATTY ACID SYNTHASE
  申请人：Infinity Pharmaceuticals, Inc.

  公开号：US20140079667A1

  公开（公告）日：2014-03-20

  Provided herein are tetrazolone FASN inhibitors of the formula (I): or a pharmaceutically acceptable form thereof; wherein the variables R A , R B and R C are defined herein. Also provided herein are pharmaceutical compositions of the compounds provided herein as well as methods of their use for the treatment of various disorders such as hyperproliferative disorders, inflammatory disorders, obesity-related disorders and microbial infections.
• US9346769B2
  申请人：——

  公开号：US9346769B2

  公开（公告）日：2016-05-24