6-methyl-7-<(n-propylamino)acetyl>-1,2,6,7-tetrahydroindolo<1,7-ab><1,5>benzodiazepine | 74116-86-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 6-methyl-7-<(n-propylamino)acetyl>-1,2,6,7-tetrahydroindolo<1,7-ab><1,5>benzodiazepine
• 英文别名: 6-methyl-7-n-propylaminoacetyl-1,2,6,7-tetrahydroindolo[1,7-ab][1,5]benzodiazepine；1-(9-Methyl-1,8-diazatetracyclo[8.6.1.02,7.014,17]heptadeca-2,4,6,10,12,14(17)-hexaen-8-yl)-2-(propylamino)ethanone
• CAS: 74116-86-2
• 化学式: C₂₁H₂₅N₃O
• 分子量: 335.449
• InChiKey: WXFLCUZLMSDEJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  35.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-methyl-7-<(n-propylamino)acetyl>-1,2,6,7-tetrahydroindolo<1,7-ab><1,5>benzodiazepine 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 生成 N-[2-(9-methyl-1,8-diazatetracyclo[8.6.1.02,7.014,17]heptadeca-2,4,6,10,12,14(17)-hexaen-8-yl)ethyl]propan-1-amine
  参考文献：
  名称：

  7-(Aminoacyl) and 7-(aminoalkyl) derivatives of 1,2,6,7-tetrahydroindolo[1,7-ab][1,5]benzodiazepines as potential antidepressant agents

  摘要：

  The synthesis of 7-(aminoacyl) and 7-(aminoalkyl) derivatives of 1,2,6,7-tetrahydroindolo[1,7-ab][1,5]benzodiazepines is described. These compounds were evaluated for antidepressant activity by their ability to inhibit tetrabenazine-induced ptosis in mice. Many compounds were found to be active in this animal model, and structure-activity relationships are discussed. Two analogues in particular, one from the 7-(aminoacyl) series (13) and one from the 7-(aminoalkyl) series (26), were of comparable potency to the antidepressant drugs desipramine and amitriptyline.

  DOI：

  10.1021/jm00186a018
• 作为产物：
  描述：

  6-methyl-1,2,6,7-tetrahydro-benzo[2,3][1,4]diazepino[6,7,1-hi]indole 在 碳酸氢钠 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 6.0h， 生成 6-methyl-7-<(n-propylamino)acetyl>-1,2,6,7-tetrahydroindolo<1,7-ab><1,5>benzodiazepine
  参考文献：
  名称：

  7-(Aminoacyl) and 7-(aminoalkyl) derivatives of 1,2,6,7-tetrahydroindolo[1,7-ab][1,5]benzodiazepines as potential antidepressant agents

  摘要：

  The synthesis of 7-(aminoacyl) and 7-(aminoalkyl) derivatives of 1,2,6,7-tetrahydroindolo[1,7-ab][1,5]benzodiazepines is described. These compounds were evaluated for antidepressant activity by their ability to inhibit tetrabenazine-induced ptosis in mice. Many compounds were found to be active in this animal model, and structure-activity relationships are discussed. Two analogues in particular, one from the 7-(aminoacyl) series (13) and one from the 7-(aminoalkyl) series (26), were of comparable potency to the antidepressant drugs desipramine and amitriptyline.

  DOI：

  10.1021/jm00186a018

文献信息

• GLAMKOWSKI E. J.; FORTUNATO J. M.; GEYER H. M., J. MED. CHEM., 1980, 23, NO 12, 1380-1386
  作者：GLAMKOWSKI E. J.、 FORTUNATO J. M.、 GEYER H. M.

  DOI：——

  日期：——
• US4192874A
  申请人：——

  公开号：US4192874A

  公开（公告）日：1980-03-11
• 7-(Aminoacyl) and 7-(aminoalkyl) derivatives of 1,2,6,7-tetrahydroindolo[1,7-ab][1,5]benzodiazepines as potential antidepressant agents
  作者：Edward J. Glamkowski、James M. Fortunato、Harry M. Geyer

  DOI：10.1021/jm00186a018

  日期：1980.12

  The synthesis of 7-(aminoacyl) and 7-(aminoalkyl) derivatives of 1,2,6,7-tetrahydroindolo[1,7-ab][1,5]benzodiazepines is described. These compounds were evaluated for antidepressant activity by their ability to inhibit tetrabenazine-induced ptosis in mice. Many compounds were found to be active in this animal model, and structure-activity relationships are discussed. Two analogues in particular, one from the 7-(aminoacyl) series (13) and one from the 7-(aminoalkyl) series (26), were of comparable potency to the antidepressant drugs desipramine and amitriptyline.