2-(5-Methyl-3-phenylindazol-1-yl)-1-morpholin-4-ylethanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(5-Methyl-3-phenylindazol-1-yl)-1-morpholin-4-ylethanone
• 英文别名: 2-(5-methyl-3-phenylindazol-1-yl)-1-morpholin-4-ylethanone
• 化学式: C₂₀H₂₁N₃O₂
• 分子量: 335.4
• InChiKey: XPBYAYUFAGDDBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  47.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] INDAZOLE DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS D'INDAZOLE ET LEURS UTILISATIONS
  申请人：WHITEHEAD BIOMEDICAL INST

  公开号：WO2014047662A2

  公开（公告）日：2014-03-27

  The present invention provides novel compounds (e.g., compounds of Formula (I)), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits comprising the inventive compounds, or compositions thereof, for treating and/or preventing a fungal or protozoan infection, inhibiting the activity of a fungal or protozoan enzyme, killing a fungus or protozoon, or inhibiting the growth of a fungus or protozoon. The fungus may be a Candida species, Aspergillus species, or other pathogenic fungal species. The compounds of the invention may inhibit the activity of fungal or protozoan cytochrome b and/or fungal or protozoan Hsp90. The present invention also provides synthetic methods of the inventive compounds.