2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-(hydroxymethyl)piperidin-4-yl]chromen-4-one;hydrochloride

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-(hydroxymethyl)piperidin-4-yl]chromen-4-one;hydrochloride
• 化学式: C21H21Cl2NO5
• 分子量: 438.3
• InChiKey: GPRMGJBHVNQRHT-ZVWHLABXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.63
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  99
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• PEPTIDES AND METHODS FOR TREATING CANCER
  申请人：Agency for Science, Technology and Research

  公开号：EP2904000A1

  公开（公告）日：2015-08-12
• STAPLING eIF4E INTERACTING PEPTIDES
  申请人：Agency for Science, Technology and Research

  公开号：EP2976354A1

  公开（公告）日：2016-01-27
• NON-MEMBRANE DISRUPTIVE p53 ACTIVATING STAPLED PEPTIDES
  申请人：Agency for Science, Technology and Research

  公开号：EP3256484A1

  公开（公告）日：2017-12-20
• METHODS FOR TREATING CASTRATION-RESISTANT AND CASTRATION- SENSITIVE PROSTATE CANCER
  申请人：Sumitomo Dainippon Pharma Oncology, Inc.

  公开号：EP3891294A1

  公开（公告）日：2021-10-13
• [EN] PEPTIDES AND METHODS FOR TREATING CANCER<br/>[FR] PEPTIDES ET MÉTHODES DE TRAITEMENT DU CANCER
  申请人：AGENCY SCIENCE TECH & RES

  公开号：WO2014055039A1

  公开（公告）日：2014-04-10

  By using a phage display derived peptide as an initial template, compounds have been developed that are highly specific against Mdm2/Mdm4. These compounds exhibit greater potency in p53 activation and protein-protein interaction assays than a compound derived from the p53 wild-type sequence. Unlike nutlin, a small molecule inhibitor of Mdm2/Mdm4, the phage derived compounds can arrest cells resistant to p53 induced apoptosis over a wide concentration range without cellular toxicity, suggesting they are highly suitable for cyclotherapy.