1-(4-methoxyphenyl)-2-(5-methyl-2-phenyl-1-tosyl-1H-indol-4-yl)ethanone | 1616350-36-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-(4-methoxyphenyl)-2-(5-methyl-2-phenyl-1-tosyl-1H-indol-4-yl)ethanone
• 英文别名: 1-(4-Methoxyphenyl)-2-[5-methyl-1-(4-methylphenyl)sulfonyl-2-phenylindol-4-yl]ethanone；1-(4-methoxyphenyl)-2-[5-methyl-1-(4-methylphenyl)sulfonyl-2-phenylindol-4-yl]ethanone
• CAS: 1616350-36-7
• 化学式: C₃₁H₂₇NO₄S
• 分子量: 509.626
• InChiKey: AEMITKCWPDKTGO-UHFFFAOYSA-N

物化性质

• 熔点：
  166.6-168.1 °C
• 沸点：
  736.9±70.0 °C(predicted)
• 密度：
  1.21±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  73.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-methyl-N-(4-methyl-2-(phenylethynyl)phenyl)benzenesulfonamide 、 [1-(4-methoxyphenyl)vinyloxy]trimethylsilane 在 亚碘酰苯 、 silver trifluoromethanesulfonate 作用下， 以 甲醇 、 乙腈 为溶剂， 反应 0.08h， 以74%的产率得到1-(4-methoxyphenyl)-2-(5-methyl-2-phenyl-1-tosyl-1H-indol-4-yl)ethanone
  参考文献：
  名称：

  One-Pot Synthesis of Highly Substituted 4-Acetonylindoles via Sequential Dearomatization and Silver-Catalyzed Domino Reaction

  摘要：

  Synthetically useful 4-acetonylindoles have been conveniently prepared from 2-alkynylanilines and silyl enol ethers using a dearomatization strategy. The two-step/one-pot protocol involves an iodosylbenzene-mediated oxidative dearomatization and a silver-catalyzed domino reaction.

  DOI：

  10.1021/ol501678v

文献信息

• One-Pot Synthesis of Highly Substituted 4-Acetonylindoles via Sequential Dearomatization and Silver-Catalyzed Domino Reaction
  作者：Xin Feng、Huiqing Wang、Bo Yang、Renhua Fan

  DOI：10.1021/ol501678v

  日期：2014.7.3

  Synthetically useful 4-acetonylindoles have been conveniently prepared from 2-alkynylanilines and silyl enol ethers using a dearomatization strategy. The two-step/one-pot protocol involves an iodosylbenzene-mediated oxidative dearomatization and a silver-catalyzed domino reaction.