1,5-Diamino-2,4-bis(4-hydroxy-3-methylphenyl)pentan-3-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1,5-Diamino-2,4-bis(4-hydroxy-3-methylphenyl)pentan-3-one
• 英文别名: 1,5-diamino-2,4-bis(4-hydroxy-3-methylphenyl)pentan-3-one
• 化学式: C₁₉H₂₄N₂O₃
• 分子量: 328.4
• InChiKey: WATACBCUDKQZQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  110
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• AMIDE COMPOUND, PREPARATION METHOD AND USES THEREOF
  申请人：Yu Zhenpeng

  公开号：US20140128463A1

  公开（公告）日：2014-05-08

  Disclosed are amide compounds, preparation method and uses thereof, specifically, the compounds represented by formula I or pharmaceutically acceptable salts, wherein R 1 , R 2 , R 3 , R 4 , R 5 , Q, X and n are defined as in the description. Also disclosed are a method for preparing the compounds of formula I, a composition containing the compounds, and the uses of the same in the preparation of medicaments for regulating blood lipid and/or preventing gallstone. The compounds of formula I disclosed in the present invention have stability in vitro, good solubility in the pharmaceutical organic solvents and favorable bioavailability in animals.

  本公开涉及酰胺化合物、其制备方法和用途，具体地说，是由式I表示的化合物或药学上可接受的盐，其中R1、R2、R3、R4、R5、Q、X和n的定义如描述中所述。还公开了一种制备式I化合物的方法，含有该化合物的组合物，以及在制备用于调节血脂和/或预防胆结石的药物中使用它的用途。本发明公开的式I化合物在体外具有稳定性，在制药有机溶剂中具有良好的溶解性，并在动物体内具有良好的生物利用度。
• Amide compound, preparation method and uses thereof
  申请人：Yu Zhenpeng

  公开号：US10428013B2

  公开（公告）日：2019-10-01

  Disclosed are amide compounds, preparation method and uses thereof, specifically, the compounds represented by formula I or pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, Q, X and n are defined as in the description. Also disclosed are a method for preparing the compounds of formula I, a composition containing the compounds, and the uses of the same in the preparation of medicaments for regulating blood lipid and/or preventing gallstone. The compounds of formula I disclosed in the present invention have stability in vitro, good solubility in the pharmaceutical organic solvents and favorable bioavailability in animals.

  本发明公开了酰胺类化合物、其制备方法和用途，特别是式 I 所代表的化合物或药学上可接受的盐类，其中 R1、R2、R3、R4、R5、Q、X 和 n 的定义如说明书所述。还公开了一种制备式 I 化合物的方法、一种含有该化合物的组合物，以及该组合物在制备调节血脂和/或预防胆石症的药物中的用途。本发明公开的式 I 化合物在体外具有稳定性，在药用有机溶剂中具有良好的溶解性，在动物体内具有良好的生物利用度。