1-allyl-2-phenylindoline | 1143570-84-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-allyl-2-phenylindoline
• 英文别名: (2R)-2-phenyl-1-prop-2-enyl-2,3-dihydroindole
• CAS: 1143570-84-6
• 化学式: C₁₇H₁₇N
• 分子量: 235.329
• InChiKey: MPDMHADGMACJEH-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,3-二氢-2-苯基-1H-吲哚 、 烯丙基甲基碳酸酯 在 bis(η3-allyl-μ-chloropalladium(II)) 、 (1R,2R)-(+)-1,2-二氨基环己烷-N,N′-双(2-二苯基磷苯甲酰) 作用下， 以 甲苯 为溶剂， 以46%的产率得到1-allyl-2-phenylindoline
  参考文献：
  名称：

  Kinetic Resolution of Indolines by Pd-Catalyzed Asymmetric Allylic Amination

  摘要：

  The kinetic resolution of indolines was realized via a Pd-catalyzed allylic substitution reaction by using Trost's chiral ligand L10, affording optically active indolines and N-allylated indolines in high yields and high enantioselectivities with an S factor up to 59, which provided the first example for the kinetic resolution of nucleophiles via a transition-metal-catalyzed allylic substitution reaction.

  DOI：

  10.1021/ol9002543

文献信息

• Kinetic Resolution of Indolines by Pd-Catalyzed Asymmetric Allylic Amination
  作者：Xue Long Hou、Bao Hui Zheng

  DOI：10.1021/ol9002543

  日期：2009.4.16

  The kinetic resolution of indolines was realized via a Pd-catalyzed allylic substitution reaction by using Trost's chiral ligand L10, affording optically active indolines and N-allylated indolines in high yields and high enantioselectivities with an S factor up to 59, which provided the first example for the kinetic resolution of nucleophiles via a transition-metal-catalyzed allylic substitution reaction.