5-[2-[5-[2-[5-[2-[5-(2-Cyclopropyl-2-hydroxypropoxy)-1-(2-fluorophenyl)pyrazole-3-carbonyl]oxy-2-ethylbutoxy]-1-(2-fluorophenyl)pyrazole-3-carbonyl]oxy-2-methylpropoxy]-1-(2-fluorophenyl)pyrazole-3-carbonyl]oxy-2-methylbutoxy]-1-(2-fluorophenyl)pyrazole-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-[2-[5-[2-[5-[2-[5-(2-Cyclopropyl-2-hydroxypropoxy)-1-(2-fluorophenyl)pyrazole-3-carbonyl]oxy-2-ethylbutoxy]-1-(2-fluorophenyl)pyrazole-3-carbonyl]oxy-2-methylpropoxy]-1-(2-fluorophenyl)pyrazole-3-carbonyl]oxy-2-methylbutoxy]-1-(2-fluorophenyl)pyrazole-3-carboxylic acid
• 英文别名: 5-[2-[5-[2-[5-[2-[5-(2-cyclopropyl-2-hydroxypropoxy)-1-(2-fluorophenyl)pyrazole-3-carbonyl]oxy-2-ethylbutoxy]-1-(2-fluorophenyl)pyrazole-3-carbonyl]oxy-2-methylpropoxy]-1-(2-fluorophenyl)pyrazole-3-carbonyl]oxy-2-methylbutoxy]-1-(2-fluorophenyl)pyrazole-3-carboxylic acid
• 化学式: C₆₁H₆₂F₄N₈O₁₃
• 分子量: 1191.2
• InChiKey: YDCLHCUALVCVTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.7
• 重原子数：
  86
• 可旋转键数：
  30
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  245
• 氢给体数：
  2
• 氢受体数：
  21

文献信息

• OXYGEN-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
  申请人：RUF Sven

  公开号：US20140128616A1

  公开（公告）日：2014-05-08

  The present invention relates to compounds of the formula I, wherein A, D, E, G, R 10 , R 30 , R 40 , R 50 and R 60 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.

  本发明涉及公式I的化合物，其中A、D、E、G、R10、R30、R40、R50和R60具有声明中指示的含义，它们是有价值的药物活性化合物。它们是蛋白酶卡特普西A的抑制剂，可用于治疗动脉硬化、心力衰竭、肾脏疾病、肝脏疾病或炎症性疾病等疾病。此外，本发明还涉及公式I化合物的制备方法、它们的用途以及包含它们的制药组合物。
• Intermediates for the synthesis of oxygen-substituted 3-heteroaroylamino-propionic acid derivatives
  申请人：SANOFI

  公开号：EP2826772A1

  公开（公告）日：2015-01-21

  The present invention relates to synthesis precursors useful for the preparation of compounds of the formula I, wherein A, D, E, G, R10, R30, R40, R50 and R60 have the meanings indicated in the description, which in turn are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example.

  本发明涉及用于制备式 I 化合物的合成前体、 其中 A、D、E、G、R10、R30、R40、R50 和 R60 的含义如说明书所示，它们是有价值的药物活性化合物。它们是蛋白酶 cathepsin A 的抑制剂，可用于治疗动脉粥样硬化、心力衰竭、肾病、肝病或炎症等疾病。