2-phenyl-5-methyl-2H-1,2,3-triazol-4-carbaldehyd | 13322-11-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-phenyl-5-methyl-2H-1,2,3-triazol-4-carbaldehyd
• 英文别名: 5-Methyl-2-phenyl-2H-1,2,3-triazol-4-aldehyd；5-Methyl-2-phenyl-2H-1,2,3-triazol-aldehyd-(4)；5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carbaldehyde；5-methyl-2-phenyl-2H-1,2,3-triazole-4-carbaldehyde；5-methyl-2-phenyltriazole-4-carbaldehyde
• CAS: 13322-11-7
• 化学式: C₁₀H₉N₃O
• 分子量: 187.201
• InChiKey: XLMBVMPACSDJMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  47.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-phenyl-5-methyl-2H-1,2,3-triazol-4-carbaldehyd 、 4-(styryl)-4'-(tributylphosphoniomethyl)biphenyl-2''-sulfonat 在 sodium hydroxide 作用下， 以 乙二醇 为溶剂， 反应 4.25h， 以44.8%的产率得到natrium <4-styryl-4'-(1''''-<2''''-phenyl-5''''-methyl-1'''',2'''',3''''-triazol-4''''-yl>-aethen-2'''-yl)biphenyl-2''-sulfonat>
  参考文献：
  名称：

  Wittig -Reaktionen von sulfonierten Phosphoniomethylstrylaromaten mit aromatischen and heteroaromatischen Aldehyden †

  摘要：

  磷甲基芳基化合物与磺化芳族和杂芳族醛的Wittig反应

  DOI：

  10.1002/hlca.19810640403

文献信息

• Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
  申请人：Kelly G. Michael

  公开号：US20060217448A1

  公开（公告）日：2006-09-28

  Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

  公开了具有以下公式代表的Bicycloheteroaryl化合物：这些化合物可以制备为药物组合物，并可用于预防和治疗包括人类在内的哺乳动物的各种疾病，例如疼痛、炎症、创伤性损伤等。
• Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof
  申请人：Kelly G Michael

  公开号：US20080039478A1

  公开（公告）日：2008-02-14

  Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

  本文披露了一种具有以下公式表示的Bicycloheteroaryl化合物：这些化合物可以制备为药物组成物，并可用于预防和治疗哺乳动物包括人类的各种疾病，包括但不限于疼痛，炎症，创伤性损伤等。
• Acyl Piperazine Derivatives as TTX-S Blockers
  申请人：Morita Mikiko

  公开号：US20130150356A1

  公开（公告）日：2013-06-13

  The present invention relates to acyl piperazine derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.

  本发明涉及酰基哌嗪衍生物，具有阻断电压门控钠通道（TTX-S通道）的活性，并且在治疗或预防涉及电压门控钠通道的疾病和疾病方面非常有用。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗涉及电压门控钠通道的疾病中使用这些化合物和组合物的用途。
• HETEROCYCLIC AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP2083816A2

  公开（公告）日：2009-08-05
• PROCESS FOR THE PURIFICATION OF HUMAN GROWTH HORMONE POLYPEPTIDES USING AFFINITY RESINS COMPRISING SPECIFIC LIGANDS
  申请人：Novo Nordisk A/S

  公开号：EP2356141A1

  公开（公告）日：2011-08-17