Methyl 1-[3-[2-[4-chloro-3-(trifluoromethyl)anilino]prop-2-enoxy]phenyl]triazole-4-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Methyl 1-[3-[2-[4-chloro-3-(trifluoromethyl)anilino]prop-2-enoxy]phenyl]triazole-4-carboxylate
• 英文别名: methyl 1-[3-[2-[4-chloro-3-(trifluoromethyl)anilino]prop-2-enoxy]phenyl]triazole-4-carboxylate
• 化学式: C₂₀H₁₆ClF₃N₄O₃
• 分子量: 452.8
• InChiKey: NLJACVUVBWKCKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  78.3
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• EP1663204B1
  申请人：——

  公开号：EP1663204B1

  公开（公告）日：2014-05-07
• POLYMIDE NUCLEIC ACID DERIVATIVES, AND AGENTS AND PROCESSES FOR PREPARING THEM
  申请人：UHLMANN Eugen

  公开号：US20110117569A1

  公开（公告）日：2011-05-19

  The present invention relates to PNA derivatives which carry, at the C terminus, or at both the C and N termini of the PNA backbone, one or more phosphoryl radicals. The phosphoryl radicals carry, where appropriate, one or more labeling groups, groups for crosslinking, groups which promote intracellular uptake, or groups which increase the binding affinity of the PNA derivative for nucleic acids. The invention furthermore relates to a process for preparing the above-mentioned PNA derivatives and to their use as pharmaceuticals or diagnostic agents.