4-[4-(4-Chlorophenyl)-2-pyridin-3-yl-1,3-thiazol-5-yl]benzenethiol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[4-(4-Chlorophenyl)-2-pyridin-3-yl-1,3-thiazol-5-yl]benzenethiol
• 英文别名: 4-[4-(4-chlorophenyl)-2-pyridin-3-yl-1,3-thiazol-5-yl]benzenethiol
• 化学式: C₂₀H₁₃ClN₂S₂
• 分子量: 380.9
• InChiKey: ZDCTYEHXPWRPNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  55
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• THIAZOLE DERIVATIVES AS ALPHA 7 NACHR MODULATORS
  申请人：Lupin Limited

  公开号：EP2945936A1

  公开（公告）日：2015-11-25
• [EN] THIAZOLE DERIVATIVES AS ALPHA 7 NACHR MODULATORS<br/>[FR] DÉRIVÉS DE THIAZOLE EN TANT QUE MODULATEURS DE NACHR ALPHA-7
  申请人：LUPIN LTD

  公开号：WO2014072957A1

  公开（公告）日：2014-05-15

  Disclosed is a compound of formula (I), wherein R1, R2, R3, R4, R5 and m are as described herein, as a modulator of nicotinic acetylcholine receptors particularly α7 subtype, its tautomeric forms, its stereoisomers, its pharmaceutically acceptable salts, its pharmaceutical composition, and its combinations with suitable medicaments. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like.