(4E,5E)-4,5-di(ethylidene)-1,3-thiazol-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (4E,5E)-4,5-di(ethylidene)-1,3-thiazol-2-amine
• 化学式: C₇H₁₀N₂S
• 分子量: 154.24
• InChiKey: RBOHFBSASMXUHV-GGWOSOGESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  63.7
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] NOVEL COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME<br/>[FR] NOUVEAU COMPOSÉ ET COMPOSITION PHARMACEUTIQUE LE CONTENANT
  申请人：ALPHALA CO LTD

  公开号：WO2019028104A1

  公开（公告）日：2019-02-07

  Disclosed are compounds of formula (I) below and pharmaceutically acceptable salts thereof: Formula (I), in which each of variables L, R3, R4, Y, Z1, Z2 and Z3 is defined herein. Also disclosed is a method for treating a cancer with a compound of formula (I) or a salt thereof and a pharmaceutical composition containing same.

  下面公开了以下式（I）的化合物及其药用盐：式（I）中，L、R3、R4、Y、Z1、Z2和Z3的每个变量均在此定义。还公开了使用式（I）的化合物或其盐治疗癌症的方法以及含有相同化合物的药物组合物。
• Small-compound enhancers for functional O-mannosylation of alpha-dystroglycan, and uses thereof
  申请人：Wu Xiaohua

  公开号：US10221168B1

  公开（公告）日：2019-03-05

  The present invention provides compounds that can enhance functional O-mannosylation of proteins including alpha-dystroglycan. Also provided are methods of preparation of the compounds defined by the formula I. Also provided are the methods of using the compounds or the pharmaceutical acceptable salts or prodrugs thereof in treating and preventing subjects suffering from the diseases including muscular dystrophies and cancers.

  本发明提供了一种可以增强蛋白质的O-甘露糖基化功能，包括α-骨骼肌糖蛋白的化合物。还提供了一种按照式I定义的化合物的制备方法。同时提供了使用这些化合物或其药用可接受的盐或前药来治疗和预防患有包括肌肉萎缩症和癌症在内的疾病的方法。
• Bicyclic heteroaryl derivatives and preparation and uses thereof
  申请人：XW LABORATORIES INC.

  公开号：US10640476B2

  公开（公告）日：2020-05-05

  The present invention relates compounds of Formula (A), as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses as modulators of dysfunctional glutamate transmission. The present invention also relates to uses of the compounds or pharmaceutical compositions in treating or preventing certain neurological and psychiatric disorders and diseases as well as cancer in humans.

  本发明涉及式（A）化合物及其制备方法和用途，还涉及包含这些化合物的药物组合物及其作为谷氨酸传递障碍调节剂的用途。本发明还涉及这些化合物或药物组合物在治疗或预防某些神经和精神疾病以及人类癌症方面的用途。
• GAMMA AMINOACIDS FOR TREATING OCULAR DISORDERS
  申请人：Case Western Reserve University

  公开号：EP2509596B1

  公开（公告）日：2019-08-28
• COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS
  申请人：Palczewski Krzysztof

  公开号：US20120295895A1

  公开（公告）日：2012-11-22

  A method of treating an ocular disorder in a subject associated with aberrant all-trans-retinal clearance in the retina, the method comprising administering to the subject a therapeutically effective amount of a primary amine compound of formula: wherein R 1 is an aliphatic and/or aromatic compound.