4-[(3-Chloro-4-methyl-2-oxo-1,3-oxazolidin-4-yl)methylsulfonyl]butanoic acid | 1310065-12-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-[(3-Chloro-4-methyl-2-oxo-1,3-oxazolidin-4-yl)methylsulfonyl]butanoic acid
• CAS: 1310065-12-3
• 化学式: C₉H₁₄ClNO₆S
• 分子量: 299.732
• InChiKey: NWJNOLGETXMAGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  109
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-(chloromethyl)-4-methyloxazolidin-2-one 在 次氯酸叔丁酯 、 水 、 sodium hydroxide 、 lithium hydroxide 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 4-[(3-Chloro-4-methyl-2-oxo-1,3-oxazolidin-4-yl)methylsulfonyl]butanoic acid
  参考文献：
  名称：

  Novel 3-chlorooxazolidin-2-ones as antimicrobial agents

  摘要：

  Antimicrobial resistance against many known therapeutics is on the rise. We examined derivatives of 3-chlorooxazolidin-2-one 1a (X = H) as antibacterial and antifungal agents. The key findings were that the activity and apparent in vitro cytotoxicity could be controlled by the substitution of charged solubilizers at the 4- and 5-positions. These changes both significantly increase the antifungal potency and decrease cytotoxicity. Particularly effective were trialkylammonium groups which led to 400- to 600-fold increases in the antifungal therapeutic index when compared to their unsubstituted counterparts. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.03.036

文献信息

• Novel 3-chlorooxazolidin-2-ones as antimicrobial agents
  作者：Timothy P. Shiau、Eric D. Turtle、Charles Francavilla、Nichole J. Alvarez、Meghan Zuck、Lisa Friedman、Donogh J.R. O’Mahony、Eddy Low、Mark B. Anderson、Ramin (Ron) Najafi、Rakesh K. Jain

  DOI：10.1016/j.bmcl.2011.03.036

  日期：2011.5

  Antimicrobial resistance against many known therapeutics is on the rise. We examined derivatives of 3-chlorooxazolidin-2-one 1a (X = H) as antibacterial and antifungal agents. The key findings were that the activity and apparent in vitro cytotoxicity could be controlled by the substitution of charged solubilizers at the 4- and 5-positions. These changes both significantly increase the antifungal potency and decrease cytotoxicity. Particularly effective were trialkylammonium groups which led to 400- to 600-fold increases in the antifungal therapeutic index when compared to their unsubstituted counterparts. (C) 2011 Elsevier Ltd. All rights reserved.