1-[3-(Dimethylamino)propyl]-4-ethyltetrazole-5-thione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-[3-(Dimethylamino)propyl]-4-ethyltetrazole-5-thione
• 英文别名: 1-[3-(dimethylamino)propyl]-4-ethyltetrazole-5-thione
• 化学式: C₈H₁₇N₅S
• 分子量: 215.32
• InChiKey: HZHZCWALTYSTQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  66.5
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• FORMULATION FOR THE SELECTIVE PHOTO ACTIVATION OF AMINO ACIDS FOR SINGLE STEP PEPTIDE COUPLING
  申请人：Vibrant Holdings, LLC

  公开号：EP3805207A1

  公开（公告）日：2021-04-14

  Disclosed herein are formulations, substrates, and arrays for amino acid and peptide synthesis on microarrays. In certain embodiments, methods for manufacturing and using the formulations, substrates, and arrays including one-step coupling, e.g., for synthesis of peptides in a C→7N orientation are disclosed. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.

  本文公开了用于在微阵列上合成氨基酸和肽的制剂、底物和阵列。在某些实施方案中，公开了制造和使用这些制剂、底物和阵列的方法，包括一步耦合，例如，用于合成 C→7N 取向的肽。在一些实施方案中，本文公开了生物大分子与基质高效偶联的制剂和方法。
• Selective photoactivation of amino acids for single step peptide coupling
  申请人：VIBRANT HOLDINGS, LLC

  公开号：US10040818B2

  公开（公告）日：2018-08-07

  Disclosed herein are formulations, substrates, and arrays for amino acid and peptide synthesis on microarrays. In certain embodiments, methods for manufacturing and using the formulations, substrates, and arrays including one-step coupling, e.g., for synthesis of peptides in a C→N orientation are disclosed. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.

  本文公开了用于在微阵列上合成氨基酸和肽的制剂、底物和阵列。在某些实施方案中，公开了制造和使用这些制剂、底物和阵列的方法，包括一步耦合，例如用于合成 C→N 取向的肽。在某些实施方案中，本文公开了生物大分子与基质高效偶联的制剂和方法。
• Substrates, systems, and methods for array synthesis and biomolecular analysis
  申请人：Vibrant Holdings, LLC

  公开号：US10286376B2

  公开（公告）日：2019-05-14

  Disclosed herein are formulations, substrates, and arrays. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays, including porous arrays. Also disclosed herein are formulations and methods for one-step coupling, e.g., for synthesis of peptides in an N->C orientation. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.

  本文公开了配方、基底和阵列。在某些实施方案中，基底和阵列包括用于合成和附着聚合物或生物分子的多孔层。本文还公开了制造和使用配方、基底和阵列（包括多孔阵列）的方法。本文还公开了用于一步偶联的配方和方法，例如用于合成 N->C 取向的肽。在某些实施方案中，本文公开了生物大分子与基质高效偶联的配方和方法。
• Methods and compositions for amplified electrochemiluminescence detection
  申请人：VIBRANT HOLDINGS, LLC

  公开号：US10816553B2

  公开（公告）日：2020-10-27

  Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.

  本文公开了配方、基底和阵列。本文还公开了制造和使用这些制剂、底物和阵列的方法。还公开了用于识别诊断和治疗疾病的多肽序列的方法，以及用于诊断和治疗疾病（如乳糜泻）的多肽序列的方法。在某些实施方案中，基底和阵列包括用于合成和附着聚合物或生物分子的多孔层。
• Peptide microarrays and novel biomarkers for celiac disease
  申请人：VIBRANT HOLDINGS, LLC

  公开号：US10900964B2

  公开（公告）日：2021-01-26

  The present disclosure relates generally to biomarkers and peptide arrays, and, more particularly, to a method of using a peptide array to identify biomarkers for an autoimmune disease such as, e.g., celiac disease. Furthermore, a set of novel biomarkers for celiac disease, having high sensitivity and specificity, are disclosed in addition to method of treatment using the novel biomarkers.

  本公开总体上涉及生物标志物和肽阵列，更具体地说，涉及一种使用肽阵列鉴定自身免疫性疾病（如乳糜泻）生物标志物的方法。此外，还公开了一组具有高灵敏度和特异性的乳糜泻新型生物标记物，以及使用这些新型生物标记物进行治疗的方法。