2-(4-((5-chloro-2-oxoindolin-3-ylidene)methyl)phenoxy)acetamide | 930552-50-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(4-((5-chloro-2-oxoindolin-3-ylidene)methyl)phenoxy)acetamide
• 英文别名: BSc3929；2-[4-[(5-chloro-2-oxo-1H-indol-3-ylidene)methyl]phenoxy]acetamide
• CAS: 930552-50-4
• 化学式: C₁₇H₁₃ClN₂O₃
• 分子量: 328.755
• InChiKey: QRXVCFKLCSFKJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  81.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-氯氧化吲哚 、 2-(4-甲酰基苯氧基)乙酰胺 在 哌啶 作用下， 以 甲醇 为溶剂， 反应 0.5h， 以43%的产率得到2-(4-((5-chloro-2-oxoindolin-3-ylidene)methyl)phenoxy)acetamide
  参考文献：
  名称：

  Inhibition of γ-secretase by the CK1 inhibitor IC261 does not depend on CK1δ

  摘要：

  CK1 and gamma-secretase are interesting targets for therapeutic intervention in the treatment of cancer and Alzheimer's disease. The CK1 inhibitor IC261 was reported to inhibit gamma-secretase activity. The question is: Does CK1 inhibition directly influence gamma-secretase activity? Therefore we analyzed the SAR of 15 analogues and their impact on gamma-secretase activity. The most active compounds were investigated on CK1 delta activity. These findings exclude a direct influence of CK1 delta on gamma-secretase, because any change in the substitution pattern of IC261 diminished CK1 inhibition, whereas gamma-secretase inhibition is still exerted by several analogues. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.02.110

文献信息

• Inhibition of γ-secretase by the CK1 inhibitor IC261 does not depend on CK1δ
  作者：Nicole Höttecke、Miriam Liebeck、Karlheinz Baumann、Robert Schubenel、Edith Winkler、Harald Steiner、Boris Schmidt

  DOI：10.1016/j.bmcl.2010.02.110

  日期：2010.5

  CK1 and gamma-secretase are interesting targets for therapeutic intervention in the treatment of cancer and Alzheimer's disease. The CK1 inhibitor IC261 was reported to inhibit gamma-secretase activity. The question is: Does CK1 inhibition directly influence gamma-secretase activity? Therefore we analyzed the SAR of 15 analogues and their impact on gamma-secretase activity. The most active compounds were investigated on CK1 delta activity. These findings exclude a direct influence of CK1 delta on gamma-secretase, because any change in the substitution pattern of IC261 diminished CK1 inhibition, whereas gamma-secretase inhibition is still exerted by several analogues. (C) 2010 Elsevier Ltd. All rights reserved.