NUCC-0176234

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: NUCC-0176234
• 英文别名: 2-[4-(4-ethylphenoxy)-1H-pyrazol-5-yl]-5-[(1-phenylpyrazol-4-yl)methoxy]phenol
• 化学式: C₂₇H₂₄N₄O₃
• 分子量: 452.513
• InChiKey: PKYRMMAAFLBYAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  85.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• SUBSTITUTED HETEROCYCLES AS c-MYC TARGETING AGENTS
  申请人：NORTHWESTERN UNIVERSITY

  公开号：US20200392116A1

  公开（公告）日：2020-12-17

  Disclosed are substituted heterocycle compounds including substituted pyrazoles, substituted pyrimidines, and substitute triazoles. The substituted heterocycles disclosed herein are shown to be useful in inhibiting c-MYC and may be utilized as therapeutics for treating cancer and cell proliferative disorders.

  本文披露了包括取代吡唑、取代嘧啶和取代三唑在内的取代杂环化合物。本文披露的取代杂环化合物被证明在抑制c-MYC方面具有用途，并可用作治疗癌症和细胞增殖性疾病的治疗药物。
• [EN] SUBSTITUTED HETEROCYCLES AS C-MYC TARGETING AGENTS<br/>[FR] HÉTÉROCYCLES SUBSTITUÉS SERVANT D'AGENTS DE CIBLAGE DE C-MYC
  申请人：UNIV NORTHWESTERN

  公开号：WO2020046382A1

  公开（公告）日：2020-03-05

  Disclosed are substituted heterocycle compounds including substituted pyrazoles, substituted pyrimidines, and substitute triazoles. The substituted heterocycles disclosed herein are shown to be useful in inhibiting c-MYC and may be utilized as therapeutics for treating cancer and cell proliferative disorders.

  本文披露了包括取代吡唑、取代嘧啶和取代三唑在内的取代杂环化合物。本文披露的取代杂环化合物已被证明在抑制c-MYC方面具有用途，并可用作治疗癌症和细胞增殖性疾病的治疗药物。
• Substituted heterocycles as c-MYC targeting agents
  申请人：Northwestern University

  公开号：US11142504B2

  公开（公告）日：2021-10-12

  Disclosed are substituted heterocycle compounds including substituted pyrazoles, substituted pyrimidines, and substitute triazoles. The substituted heterocycles disclosed herein are shown to be useful in inhibiting c-MYC and may be utilized as therapeutics for treating cancer and cell proliferative disorders.

  公开的取代杂环化合物包括取代吡唑、取代嘧啶和取代三唑。本文所公开的取代杂环化合物具有抑制 c-MYC 的作用，可用作治疗癌症和细胞增殖性疾病的药物。
• SPECIFIC 2-(4-(PHENOXY)-1H-PYRAZOL-3-YL)PHENOL DERIVATIVES AS INHIBITORS OF C-MYC/DNA BINDING ACTIVITY FOR TREATING CANCER
  申请人：Northwestern University

  公开号：EP3426636B1

  公开（公告）日：2021-12-29
• [EN] SUBSTITUTED HETEROCYCLES AS c-MYC TARGETING AGENTS<br/>[FR] HÉTÉROCYCLES SUBSTITUÉS SERVANT D'AGENTS DE CIBLAGE DE C-MYC
  申请人：UNIV NORTHWESTERN

  公开号：WO2020257261A1

  公开（公告）日：2020-12-24

  Disclosed are substituted heterocycle compounds including substituted pyrazoles, substituted pyrimidines, and substitute tri azoles. The substituted heterocycles disclosed herein are shown to be useful in inhibiting c-MYC and may be utilized as therapeutics for treating cancer and cell proliferative disorders.