2-(2-Amino-1,3-thiazol-5-yl)hexanethial

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(2-Amino-1,3-thiazol-5-yl)hexanethial
• 英文别名: 2-(2-amino-1,3-thiazol-5-yl)hexanethial
• 化学式: C₉H₁₄N₂S₂
• 分子量: 214.4
• InChiKey: CWCSNIDKDRXCCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  99.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• USE OF ITK INHIBITORS FOR THE TREATMENT OF CANCER
  申请人：The University of North Carolina at Chapel Hill

  公开号：US20160000788A1

  公开（公告）日：2016-01-07

  This invention relates generally to the use of ITK (IL-2 inducible T-cell kinase) inhibitors for the treatment of patients who have melanoma or other solid tumors. Applicants demonstrate that ITK lentiviral small hairpin RNA knockdowns and a small molecule inhibitor can each decrease the proliferation and migration of melanoma cell lines and a small molecule inhibitor can be used to inhibit the growth of melanomas in vivo.
• TREATING ORGAN-SPECIFIC T CELL MEDIATED AUTOIMMUNE DISEASES
  申请人：UNIVERSITY OF MASSACHUSETTS

  公开号：US20160250208A1

  公开（公告）日：2016-09-01

  The specification provides methods of treating a subject with an organ-specific T cell mediated autoimmune disease.
• US9649313B2
  申请人：——

  公开号：US9649313B2

  公开（公告）日：2017-05-16
• [EN] USE OF ITK INHIBITORS FOR THE TREATMENT OF CANCER<br/>[FR] UTILISATION D'INHIBITEURS D'ITK POUR LE TRAITEMENT DU CANCER
  申请人：UNIV NORTH CAROLINA

  公开号：WO2014082085A1

  公开（公告）日：2014-05-30

  This invention relates generally to the use of ITK (IL-2 inducible T-cell kinase) inhibitors for the treatment of patients who have melanoma or other solid tumors. Applicants demonstrate that ITK lentiviral small hairpin RNA knockdowns and a small molecule inhibitor can each decrease the proliferation and migration of melanoma cell lines and a small molecule inhibitor can be used to inhibit the growth of melanomas in vivo.
• [EN] TREATING ORGAN-SPECIFIC T CELL MEDIATED AUTOIMMUNE DISEASES<br/>[FR] TRAITEMENT DE MALADIES AUTO-IMMUNES MÉDIÉES PAR DES LYMPHOCYTES T ORGANO-SPÉCIFIQUES
  申请人：UNIV MASSACHUSETTS

  公开号：WO2015054612A1

  公开（公告）日：2015-04-16

  The specification provides methods of treating a subject with an organ-specific T cell mediated autoimmune disease.