2-[2-[2-(5-Amino-1,3-thiazol-2-yl)ethylsulfanyl]ethyl]-1,3-thiazol-5-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[2-[2-(5-Amino-1,3-thiazol-2-yl)ethylsulfanyl]ethyl]-1,3-thiazol-5-amine
• 英文别名: 2-[2-[2-(5-amino-1,3-thiazol-2-yl)ethylsulfanyl]ethyl]-1,3-thiazol-5-amine
• 化学式: C₁₀H₁₄N₄S₃
• 分子量: 286.4
• InChiKey: SRUNGBPTHNLKCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  160
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• METHODS FOR TREATING POLYCYSTIC KIDNEY DISEASE
  申请人：Skolnik Edward

  公开号：US20150065486A1

  公开（公告）日：2015-03-05

  Methods for treating autosomal dominant polycystic kidney disease (ADPKD) are described herein. More particularly, methods described herein relate generally to administering glutaminase1 inhibitors to subjects afflicted with ADPKD. Accordingly, the use and application of compounds or agents that inhibit glutaminase1 for treating ADPKD or for use in a medicament for treating ADPKD are encompassed herein.
• US9457016B2
  申请人：——

  公开号：US9457016B2

  公开（公告）日：2016-10-04
• [EN] GLUTAMASE INHIBITORS AND METHOD OF USE<br/>[FR] INHIBITEURS DE GLUTAMASE ET LEUR PROCÉDÉ D'UTILISATION
  申请人：AGIOS PHARMACEUTICALS INC

  公开号：WO2014081925A1

  公开（公告）日：2014-05-30

  Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.