4-[8-amino-3-[1-[[(E)-4-methoxybut-2-enoyl]-methylamino]ethyl]imidazo[1,5-a]pyrazin-1-yl]-N-(4-propylpyridin-2-yl)benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[8-amino-3-[1-[[(E)-4-methoxybut-2-enoyl]-methylamino]ethyl]imidazo[1,5-a]pyrazin-1-yl]-N-(4-propylpyridin-2-yl)benzamide
• 化学式: C₂₉H₃₃N₇O₃
• 分子量: 527.6
• InChiKey: MLTDRWWLOQXKSB-SOFGYWHQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  128
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• 4-imidazopyridazin-1-yl-benzamides as BTK inhibitors
  申请人：Merck Sharp & Dohme B.V.

  公开号：US10239883B2

  公开（公告）日：2019-03-26

  The present invention relates to 6-5 membered fused pyridine ring compounds according to Formula (I) or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds according to Formula (I) in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.

  本发明涉及符合式 (I) 的 6-5 位融合吡啶环化合物 或其药学上可接受的盐，或包含这些化合物的药物组合物，以及它们在治疗中的用途。特别是，本发明涉及根据式（I）的 6-5 位融合吡啶环化合物在治疗布鲁顿酪氨酸激酶（Btk）介导的疾病中的用途。
• 4-imidazopyridazin-1-yl-benzamides as Btk inhibitors
  申请人：Merck Sharp & Dohme B.V.

  公开号：US10934296B2

  公开（公告）日：2021-03-02

  The present invention relates to 6-5 membered fused pyridine ring compounds according to Formula (I) or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds according to Formula (I) in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.

  本发明涉及符合式 (I) 的 6-5 位融合吡啶环化合物 或其药学上可接受的盐，或包含这些化合物的药物组合物，以及它们在治疗中的用途。特别是，本发明涉及根据式（I）的 6-5 位融合吡啶环化合物在治疗布鲁顿酪氨酸激酶（Btk）介导的疾病中的用途。
• 4-IMIDAZOPYRIDAZIN-1-YL-BENZAMIDES AS BTK INHIBITORS
  申请人：Merck Sharp & Dohme B.V.

  公开号：US20180179212A1

  公开（公告）日：2018-06-28

  The present invention relates to 6-5 membered fused pyridine ring compounds according to Formula (I) or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds according to Formula (I) in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.