Provided is a heterocyclic compound having an RORγt inhibitory activity. A compound represented by the formula (I):
wherein
ring A is an optionally substituted cyclic group,
Q is a bond, optionally substituted C1-10 alkylene, optionally substituted C2-10 alkenylene, or optionally substituted C2-10 alkynylene,
R1 is a substituent,
ring B is a thiazole ring, an isothiazole ring or a dihydrothiazole ring, each of which is optionally further substituted by a substituent in addition to R2, and
R2 is an optionally substituted cyclyl-carbonyl-C1-6 alkyl group, an optionally substituted aminocarbonyl-C1-6 alkyl group, an optionally substituted cyclyl-C1-6 alkyl group, an optionally substituted cyclyl-C1-6 alkylamino-carbonyl group, an optionally substituted aminocarbonyl-C2-6 alkenyl group, an optionally substituted C1-6 alkylcarbonylamino-C1-6 alkyl group, an optionally substituted cyclyl-aminocarbonyl group, an optionally substituted cyclyl-carbonyl group or an optionally substituted non-aromatic heterocyclic group,
or a salt thereof.
提供了一种具有 RORγt 抑制活性的
杂环化合物。由式(I)代表的化合物:
其中
环 A 是任选取代的环状基团、
Q 是键、任选取代的 C1-10 亚烷基、任选取代的 C2-10 烯基或任选取代的 C2-10 亚炔基、
R1 是取代基、
环 B 是
噻唑环、
异噻唑环或二氢
噻唑环,其中每个环除了 R2 之外还可选地被一个取代基进一步取代,以及
R2 是任选取代的环羰基-C1-6 烷基、任选取代的
氨基羰基-C1-6 烷基、任选取代的环羰基-C1-6 烷基、任选取代的环羰基-C1-6 烷基
氨基羰基、任选取代的
氨基羰基-C2-6 烯基、任选取代的 C1-6 烷基羰基
氨基-C1-6 烷基、任选取代的环
氨羰基、任选取代的环羰基或任选取代的非芳香杂环基团、
或其盐。