tert-butyl 2-[3-[(1R)-3-(3,4-dimethylphenyl)-1-hydroxypropyl]phenoxy]acetate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: tert-butyl 2-[3-[(1R)-3-(3,4-dimethylphenyl)-1-hydroxypropyl]phenoxy]acetate
• 化学式: C₂₃H₃₀O₄
• 分子量: 370.5
• InChiKey: PXTCRWZGWMDNJP-OAQYLSRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• BIOORTHOGONAL CHEMICAL INDUCERS OF REVERSIBLE DIMERIZATION FOR CONTROL OF PROTEIN FUNCTION IN CELLS
  申请人：MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.

  公开号：US20150168420A1

  公开（公告）日：2015-06-18

  The present application refers to bioorthogonal chemical inducers of reversible dimerization for control of protein interactions in cells. A compound, a test system, methods and uses are disclosed how the invention can be applied in the investigation of intracellular protein interactions. The system is composed of a compound of the general formula (I) as the dimerizer, displaying a high affinity binding to FKBP(F36V) mutant and eDHFR, respectively. The system is reversible on addition of TMP.

  本申请涉及用于控制细胞内蛋白相互作用的生物正交化学诱导剂的可逆二聚体化。本发明公开了一种化合物、测试系统、方法和用途，可以在细胞内蛋白质相互作用的研究中应用本发明。该系统由一般式（I）的化合物作为二聚体化剂组成，分别显示对FKBP（F36V）突变体和eDHFR具有高亲和力结合。该系统在添加TMP后是可逆的。
• PHOTOCLEAVABLE LINKER
  申请人：City of Hope

  公开号：US20140154775A1

  公开（公告）日：2014-06-05

  There are provided, inter alia, photolabile compounds and methods useful for the formation of dimers of biological molecules and subsequent dissociation of the dimers.
• Small-Molecule Hydrophobic Tagging of Fusion Proteins and Induced Degradation of Same
  申请人：YALE UNIVERSITY

  公开号：US20170067874A1

  公开（公告）日：2017-03-09

  The present invention includes compounds that are useful in perturbing or disrupting the function of a transmembrane or intracellular protein, whereby binding of the compounds to the transmembrane or intracellular protein induces proteasomal degradation of the transmembrane or intracellular protein. The present invention further includes a method of inducing proteasomal degradation of a transmembrane or intracellular protein. The present invention further includes a method of identifying or validating a protein of interest as a therapeutic target for treatment of a disease state or condition
• US9096844B2
  申请人：——

  公开号：US9096844B2

  公开（公告）日：2015-08-04
• US9260710B2
  申请人：——

  公开号：US9260710B2

  公开（公告）日：2016-02-16