(2R,3S,4S,5R)-2-(hydroxymethyl)-6-[(2-phenyl-3,4-dihydro-2H-chromen-3-yl)oxy]oxane-3,4,5-triol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: (2R,3S,4S,5R)-2-(hydroxymethyl)-6-[(2-phenyl-3,4-dihydro-2H-chromen-3-yl)oxy]oxane-3,4,5-triol
• 化学式: C₂₁H₂₄O₇
• 分子量: 388.4
• InChiKey: XCCFSPWQISPIAM-UCDWYGIPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  109
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• AN EDIBLE COMPOSITION COMPRISING RESVERATROL AND FLAVONOID MONOGLUCOSIDE
  申请人：Unilever PLC

  公开号：EP2928323A1

  公开（公告）日：2015-10-14
• AN EDIBLE COMPOSITION COMPRISING RESVERATROL AND FLAVONOID MONOGLUCOSIDE.
  申请人：Unilever PLC

  公开号：EP2928323B1

  公开（公告）日：2018-01-03
• US9943535B2
  申请人：——

  公开号：US9943535B2

  公开（公告）日：2018-04-17
• [EN] AN EDIBLE COMPOSITION COMPRISING RESVERATROL AND FLAVONOID MONOGLUCOSIDE<br/>[FR] COMPOSITION COMESTIBLE CONTENANT DU RESVÉRATROL ET UN FLAVONOÏDE MONOGLUCOSIDIQUE
  申请人：UNILEVER PLC

  公开号：WO2014086632A1

  公开（公告）日：2014-06-12

  Foods or meals high in available carbohydrate such as sucrose or starch increase postprandial blood glucose concentrations. Repeated high post-prandial plasma glucose ''spikes'' are associated with an increased risk of developing type II diabetes. Unregulated glycemic excursions are undesirable, and any reduction or ''blunting'' of the post-prandial glucose concentration in blood is potentially beneficial. This invention relates to an edible composition for delay of intestinal glucose uptake through synergistic inhibition of both active sodium glucose co-transporter 1 (SGLT1) and passive glucose transporter 2 (GLUT2) leading to flattening or blunting of the post-prandial glucose peak. In a first aspect of the invention, an edible composition is provided, in the form of a single serving of one or more unit dosages, wherein the edible composition comprises 20-2000, preferably 30-1000, most preferably 40-500 mg a 3,5-dihydroxy-trans-stilbene and 10-2000, preferably 20-1000, most preferably 40-500 mg flavonoid monoglucoside or dihydrochalcone monoglucoside.